Present Status of Organotoxicity of Inhalation Anesthetics
The introduction of halothane into clinical practice in 1958 ushered in a new era of anesthesia. This potent, nonflammable drug permitted rapid and easily controlled anesthesia depth, coupled with safe use of electrocautery by the surgeon. Perhaps the greatest boom was the quantal leap into the era of sophisticated electronic monitoring permitted by the nonflammable nature of this anesthestic. Because of space-age monitoring abilities coupled directly with increasing knowledge of physiology and pathophysiology, surgical procedures considered too dangerous and complex are now performed routinely.
KeywordsHepatic Necrosis Halothane Anesthesia Inhalation Anesthetic Reductive Pathway Halothane Hepatitis
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