Metabolism and Acute Toxicity of Volatile Anesthetics

  • V. Hempel
  • W. Heipertz
  • H-V Gärtner
  • M. Schmelzle
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)


It is well documented that the halogenated methane derivatives CCl4 and to a lesser extent CHCl3, and therefore also the anesthetic chloroform, which was used until well into the sixties, are hepatotoxic [10]. There is also good reason to suspect that halothane might also occasionally cause liver reactions leading to lethal hepatic necrosis [5].


Hepatic Lesion Volatile Anesthetic Hepatic Necrosis Halothane Anesthesia Inhalation Anesthetic 
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  1. 1.
    Bermann ML, Kunert L, Phythyon JM, Holaday DA (1983) Isoflurane and enflurane-induced hepatic necrosis in triiodthydronine-pretreated rats. Anesthesiology 58: 1CrossRefGoogle Scholar
  2. 2.
    Bloxam DL (1967) Effects of various anaesthetics on the metabolism and general condition of the isolated perfused rat liver. Biochem Pharmacol 16: 283PubMedCrossRefGoogle Scholar
  3. 3.
    Halsey MJ, Sawyer DC, Eger I II, et al. (1971) Hepatic metabolism of halothane, methoxyflurane, cyclopropane, ethrane and forane in miniature swine. Anesthesiology 35: 262CrossRefGoogle Scholar
  4. 4.
    Klatskin G (1969) In: Schmitt L (ed) Diseases of the liver. Lippincott, PhiladelphiaGoogle Scholar
  5. 5.
    Klion FM, Schaffner P, Popper H (1969) Hepatitis after exposure to halothane. Ann Intern Med 71: 467PubMedGoogle Scholar
  6. 6.
    Lewis JH, Zimmermann HJ, Ishak KG, Mullick FG (1983) Enflurane hepatotoxicity. A clinicopathologic study. Ann Intern Med 98: 984PubMedGoogle Scholar
  7. 7.
    Mazze RI, Calverley MD, Schmith N T (1977) Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers. Anesthesiology 46: 265PubMedCrossRefGoogle Scholar
  8. 8.
    Mc Lain GE, Sipes JG, Brown BR Jr (1979) An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. Anesthesiology 51: 321CrossRefGoogle Scholar
  9. 9.
    National Halothane Study (1969) Government Printing Office, Washington D CGoogle Scholar
  10. 10.
    Recknagel RO (1967) Carbon tetrachloridehepatotoxicity. Pharmacol Rev 19, 2: 145PubMedGoogle Scholar
  11. 11.
    Ross WT, Daggy BP, Cardeil RR (1979) Hepatic necrosis caused by halothane and hypoxia. Anesthesiology 51: 327PubMedCrossRefGoogle Scholar
  12. 12.
    Sawyer DC, Eger EI II, Bahiman SH, et al. (1971) Concentration dependence of hepatic halothane metabolism. Anesthesiology 34: 230PubMedCrossRefGoogle Scholar
  13. 13.
    Sharp JH, Trudell JR, Cohen EN (1979) Volatile metabolites and decomposition products of halo-thane in man. Anesthesiology 50: 2PubMedCrossRefGoogle Scholar
  14. 14.
    Uehleke H, Hellmer KH, Tabarelli-Poplawski S (1973) Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro. Arch Exp Pathol Pharmacol 279: 39CrossRefGoogle Scholar
  15. 15.
    Widger LA, Gandolfi AJ, Van Dyke RA (1976) Hypoxie and halothane metabolism in vivo. Anesthesiology 44: 197PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • V. Hempel
  • W. Heipertz
  • H-V Gärtner
  • M. Schmelzle

There are no affiliations available

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