Pharmacokinetics of Inhalation Anesthetics Studied with a Feedback-Controlled Closed System
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During the ether era, the anesthetic was dosed following the classical signs pertaining to anesthetic depth as described by Guedel. Today with the new inhalational agents, these signs are less well defined, and valid only during the induction phase as, for instance, the drop in blood pressure or the change in respiratory rate if the patient is allowed to breathe spontaneously . Consequently, anesthetic dosage is gernally based on the experience and or “touch” of the anesthetist. Eger  introduced the concept of MAC (minimal alveolar concentration) in order to compare the potency of various inhalational agents. The MAC value is however, only helpful if either the concentration delivered to the patient (the inspired concentration) or the concentration in the end-tidal air can be measured.
KeywordsMinimal Alveolar Concentration Inhalation Anesthetic Inhalational Agent Anesthetic Concentration Arterial Concentration
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