Pharmacokinetics of Inhalation Anesthetics Studied with a Feedback-Controlled Closed System

  • D. Thomson
  • A. M. Zbinden
  • D. Westenskow
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)


During the ether era, the anesthetic was dosed following the classical signs pertaining to anesthetic depth as described by Guedel. Today with the new inhalational agents, these signs are less well defined, and valid only during the induction phase as, for instance, the drop in blood pressure or the change in respiratory rate if the patient is allowed to breathe spontaneously [1]. Consequently, anesthetic dosage is gernally based on the experience and or “touch” of the anesthetist. Eger [2] introduced the concept of MAC (minimal alveolar concentration) in order to compare the potency of various inhalational agents. The MAC value is however, only helpful if either the concentration delivered to the patient (the inspired concentration) or the concentration in the end-tidal air can be measured.


Minimal Alveolar Concentration Inhalation Anesthetic Inhalational Agent Anesthetic Concentration Arterial Concentration 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • D. Thomson
  • A. M. Zbinden
  • D. Westenskow

There are no affiliations available

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