Comparative Pharmacodynamics of Halogenated Anesthetics: Quantitative EEG Analysis to Objectify Central Nervous Effects

  • H. Stoeckel
  • H. Schwilden
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)


During anesthesia the EEG is monitored for three purposes:
  1. 1.

    As an indicator for hazardous, e.g., hypoxic conditions of the brain [5, 9]

  2. 2.

    As a quantifiable pharmacodynamic effect of anesthetics with central action and to document their availability at the site of action (pharmaco EEG) [2]

  3. 3.

    As an indicator of an objectifiable depth of anesthesia expressable numerically [11]



Volatile Anesthetic Minimal Alveolar Concentration Awake State Delta Activity Objectifiable Depth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Faulconer A, Bickford RG (eds) (1960) Electroencephalography in anesthesiology. Thomas, SpringfieldGoogle Scholar
  2. 2.
    Herrman M (ed) (1982) Electroencephalography in drug research. Fischer, StuttgartGoogle Scholar
  3. 3.
    Kubicki KS, Herrmann WM, Laudahn G (eds) (1980) Factor analysis and EEG variables. Fischer, StuttgartGoogle Scholar
  4. 4.
    Newberg LA, Milde JK, Michenfelder JD (1983) The cerebral metabolic effects of isoflurane at and above concentrations that suppress cortical electrical activity. Anesthesiology 59: 23PubMedCrossRefGoogle Scholar
  5. 5.
    Prior PF (1985) EEG monitoring and evoked potentials in brain ischaemia. Br J Anaesth 57: 63PubMedCrossRefGoogle Scholar
  6. 6.
    Schwilden H, Stoeckel H (1980) Untersuchungen über verschiedene EEG-Parameter als Indikatoren des Narkosezustandes. Anaesth Intensivther Notfallmed 15: 279CrossRefGoogle Scholar
  7. 7.
    Schwilden H, Stoeckel H (1982) Faktorenanalyse der Frequenzbandverteilung des EEG’s während Halothan- und Enflurannarkosen. In: Peter K, Jesch F (eds) Inhalationsanaesthesie heute und morgen. Springer, Berlin Heidelberg New York, p 143 (Anaesthesiology and intensive care medicine, vol 149 )Google Scholar
  8. 8.
    Schwilden H, Stoeckel H (1985) The derivation of EEG parameters for modelling and control of anaesthetic drug effect. In: Stoeckel H (ed) Quantitation, modelling and control of anaesthesia. Thieme and Stratton, StuttgartGoogle Scholar
  9. 9.
    Shapiro HM (1985) Barbiturates in brain ischaemia. Br J Anaesth 57: 82PubMedCrossRefGoogle Scholar
  10. 10.
    Stoeckel H, Schwilden H, Lauven PM, Schüttler J (1981) EEG indices for evaluation of depth of anaesthesia. Br J Anaesth 53: 117Google Scholar
  11. 11.
    Stoeckel H, Schwilden H (1984) Quantitative EEG analysis and monitoring depth of anaesthesia. In: Gomez QJ, Egay LM, de la Cruz-Odi MF (eds) Anaesthesia-safety for All. Elsevier, Amsterdam, p 151Google Scholar
  12. 12.
    Gisvold SE, Steen PA (1985) Drug therapy in brain ischaemia. Br J Anaesth 57, 96PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H. Stoeckel
  • H. Schwilden

There are no affiliations available

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