Volatile Anesthetics and Heart Failure

  • P. Foëx
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)


The modern inhalational anaesthetics halothane, enflurane and isoflurane are known to depress myocardial contractility. This has been repeatedly demonstrated in isolated heart muscle preparations and in intact hearts, in experimental animals as well as in man. This depression is directly proportional to the concentration of the inhalational agent used. The overall effect of these agents on the circulation depends not only on their direct effect on myocardial contractility but also on their effect on vascular resistance and capacitance. Moreover, alterations of baroreceptor sensitivity occur during the administration of inhalational anaesthetics and this, in turn, will modify the regulation of blood pressure and heart rate.


Myocardial Contractility Volatile Anesthetic Contractile Element Inhalational Anaesthetic Intact Heart 
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© Springer-Verlag Berlin Heidelberg 1987

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  • P. Foëx

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