Volatile Anesthetics and Heart Failure
The modern inhalational anaesthetics halothane, enflurane and isoflurane are known to depress myocardial contractility. This has been repeatedly demonstrated in isolated heart muscle preparations and in intact hearts, in experimental animals as well as in man. This depression is directly proportional to the concentration of the inhalational agent used. The overall effect of these agents on the circulation depends not only on their direct effect on myocardial contractility but also on their effect on vascular resistance and capacitance. Moreover, alterations of baroreceptor sensitivity occur during the administration of inhalational anaesthetics and this, in turn, will modify the regulation of blood pressure and heart rate.
KeywordsMyocardial Contractility Volatile Anesthetic Contractile Element Inhalational Anaesthetic Intact Heart
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