Blood Flow and Oxygen Supply of the Myocardium Under Isoflurane and Enflurane

  • J. Hobbhahn
  • P. Conzen
  • A. Goetz
  • H. Habazettl
  • T. Granetzny
  • W. Brendel
  • K. Peter
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)


Studies of myocardial blood flow under isoflurane performed so far have resulted in controversal findings: on the one hand a decline of myocardial blood flow with unchanged or minimally declining vascular resistance [2, 9, 10], and on the other hand a weakly [14] or strongly [3, 15] increasing blood flow of the myocardium with a profound decline of coronary vascular resistance have been described.


Mean Arterial Pressure Myocardial Blood Flow Coronary Perfusion Pressure Pancuronium Bromide Coronary Vascular Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Fischer KJ (1979) Der Einfluß von Anaesthetika auf die Kontraktionsdynamik des Herzens. Springer, Berlin Heidelberg New York (Anaesthesiologie und Intensivmedizin, vol 117 )Google Scholar
  2. 2.
    Fitzal S (1984) Inhalationsanästhetika und Myokardfunktion. Pharmakodynamische und pharmakokinetische Untersuchungen. Maudrich, Vienna (Beiträge zur Anästhesiologie und Intensivmedizin vol 4 )Google Scholar
  3. 3.
    Gelman S, Fowler K, Smith L (1983) Cardiac output distribution and regional blood flow during isoflurane anesthesia. Anesthesiology 59: A 68CrossRefGoogle Scholar
  4. 4.
    Kessler M, Lübbers DW (1966) Aufbau und Anwendungsmöglichkeiten verschiedener pO2-Elektroden. Pflügers Arch Ges Physiol 291:R 32Google Scholar
  5. 5.
    Kessler M, Höper J, Schäfer D, Starlinger H (1974) Sauerstofftransport im Gewebe. In: Ahnefeld FW, Burri C, Dick W, Halmagy M (eds) Mikrozirkulation. Springer, Berlin Heidelberg New York, 36 (Klinische Anästhesiologie und Intensivtherapie, vol 5 )Google Scholar
  6. 6.
    Koblin DD, Eger EI II, Johnson BH, Collins P, Harper MH, Terrell RC, Speers L (1981) Minimum alveolar concentrations and oil/gas partition coefficients of four anesthetic isomers. Anesthesiology 54: 314PubMedCrossRefGoogle Scholar
  7. 7.
    Larsen R, Hilfiker O, Merkel G, Sonntag H, Drobnik L (1984) Myocardial oxygen balance during Enflurane and Isoflurane anesthesia for coronary artery surgery. Anesthesiology 61: A 4Google Scholar
  8. 8.
    Lübbers DW (1977) Die Bedeutung des lokalen Gewebesauerstoffdruckes und des pO2-Histogramms für die Beurteilung der Sauerstoffversorgung eines Organs. Prakt Anästh 12: 184Google Scholar
  9. 9.
    Lundeen G, Manohar M, Parks C (1983) Systemic distribution of blood flow in swine while awake and during 1.0 and 1.5 MAC Isoflurane anesthesia with or without 50% nitrous oxide. Anaesth Analg 62: 499CrossRefGoogle Scholar
  10. 10.
    Merin RG (1981) Are the myocardial functional and metabolic effects of Isoflurane really different from those of halothane and enflurane? Anesthesiology 55: 398PubMedCrossRefGoogle Scholar
  11. 11.
    Reiz S, Balfors E, Sorensen MB, Ariola S, Friedman A, Truedsson H (1983) Isoflurane - a powerful coronary vasodilator in patients with coronary artery disease. Anesthesiology 59: 91PubMedCrossRefGoogle Scholar
  12. 12.
    Rudolph AM, Heymann MA (1967) The circulation of the fetus in utero. Circ Res 21: 163PubMedGoogle Scholar
  13. 13.
    Stevens WC, Cromwell TH, Halsy MJ, Eger EI II, Shakespeare TF, Bahlman SH (1971) The cardiovascular effects of a new inhalation anesthetic, Forane in human volunteers at constant arterial carbon dioxide tension. Anesthesiology 35: 8PubMedCrossRefGoogle Scholar
  14. 14.
    Tarnow J, Eberlein HJ, Oser G, Patschke D, Schneider E, Schweichel E, Wilde J (1977) Hämodynamik, Myokardkontraktilität, Ventrikelvolumina und Sauerstoffversorgung des Herzens unter verschiedenen Inhalationsanästhetika. Anaesthesist 26: 220PubMedGoogle Scholar
  15. 15.
    Vogel H, Günther H, Harrison DK, Kessler M, Peter K (1984) The influence of isoflurane and enflurane on tissue oxygenation and microcirculation of the dog myocardium. Anesthesiology 61: A 5Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. Hobbhahn
  • P. Conzen
  • A. Goetz
  • H. Habazettl
  • T. Granetzny
  • W. Brendel
  • K. Peter

There are no affiliations available

Personalised recommendations