Advertisement

Cardiodynamics During Rapid Volume Expansion and Function of Chronically Ischemic Myocardium Under Isoflurane: A Study in Chronically Instrumented Dogs

  • M. Zimpfer
  • N. Mayer
  • H. Gilly
  • E. Maurer
  • K. Steinbereithner
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)

Abstract

Volatile anesthetics have a negatively inotropic effect and therefore influence the function of the ischemic and nonischemic myocardium. It may also be assumed that the simultaneously induced peripheral vasodilatation has major consequences for the cardiodynamics during various forms of inhalation anesthesia [16, 28, 29]. It was the purpose of this study to examine the effects of increasing concentrations of isoflurane 1) on cardiodynamics under acute volume expansion and 2) on the contractile function of chronically ischemic myocardium on the basis of measurements of segmental left ventricular function.

Keywords

Coronary Blood Flow Volatile Anesthetic Left Atrial Pressure Inhalation Anesthesia Regional Myocardial Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Beck A, Zimpfer M, Raberger G (1982) Inhibition of the carotid chemoreceptor reflex by enflurane in chronically instumented dogs. Naunyn-Schmiedbergs Arch Pharmacol 321: 145–148CrossRefGoogle Scholar
  2. 2.
    Bland JHL, Lowenstein E (1976) Halothane-induced decrease in experimental myocardial ischemia in the non-failing canine heart. Anesthesiology 45: 287–293PubMedCrossRefGoogle Scholar
  3. 3.
    Boettcher DH, Vatner SF, Heyndrickx GR, Braunwald E (1978) Extent of utilization of the Frank- starling mechanism in conscious dogs. Am J Physiol 234: H338–H345PubMedGoogle Scholar
  4. 4.
    Boettcher DH, Zimpfer M, Vatner SF (1982) Phylogenesis of the Bainbridge reflex. Am J Physiol 242: R244–R246PubMedGoogle Scholar
  5. 5.
    Cohn LH, Klovekorn P, Moore FD, Collins JJ, Jr (1974) Intrinsic plasma volume deficites in patients with coronary artery disease. Arch Surg 180: 57–60Google Scholar
  6. 6.
    Cox RH, Bagashaw FJ (1979) Influence of anesthesia on the response to carotid hypotension in dogs. Am J Physiol 237: H424–H432PubMedGoogle Scholar
  7. 7.
    Francis CM, Foex P, Lowenstein E, Glazebrook CW, Davies WL, Ryder WA, Jones LA (1982) Interaction between regional myocardial ischemia and left ventricular performance under halothane anaesthesia. Br J Anaesth 54: 965–980PubMedCrossRefGoogle Scholar
  8. 8.
    Gelman S, Fowler KC, Smith LR (1984) Regional blood flow during isoflurane and halothane anesthesia. Anaesth Analg 63: 557–565Google Scholar
  9. 9.
    Hanson EL, Kane PB, Askanazi J, Neville JF, Jr, Webb WR (1976) Intraoperative differences of blood volume and observations of vasomotor response. Ann Thorac Surg 22: 343PubMedCrossRefGoogle Scholar
  10. 10.
    Lowenstein E, Foëx P, Francis CM, Davies LW, Yusuf S, Ryder AW (1981) Regional ischemic ventricular dysfunction in myocardium supplied by a narrowes coronary artery with increasing halothane concentrations in the dog. Anesthesiology 55: 349–359PubMedCrossRefGoogle Scholar
  11. 11.
    Mayer N, Kotai E, Placheta P, Steinbereithner K, Zimpfer M (1984) Enflurane alters compensatory humoral and hemodynamic responses to hemorrhage. Syllabus Annual Meeting of the Society of Cardiovascular AnesthesiologistsGoogle Scholar
  12. 12.
    Merin RG (1981) Are the myocardial functional metabolic effects of isoflurane really different from those of halothane and enflurane? Anesthesiology 55: 398–408PubMedCrossRefGoogle Scholar
  13. 13.
    Patrick TA, Vatner SF, Kemper WS, Franklin D (1974) Telemetry of left ventricular diameter and pressure measurements from unrestrained animals. J Appl Physiol 37: 276–281PubMedGoogle Scholar
  14. 14.
    Reiz S, Balfors E, Sorensen MB, Ariola S, Friedman A, Truedsson H (1983) Isoflurane — a powerful coronary vasodilator in patients with coronary artery disease. Anesthesiology 59: 91–97PubMedCrossRefGoogle Scholar
  15. 15.
    Sarnoff SJ, Mitchell JH (1961) The regulation of the performance of the heart. Am J Physiol 30: 747–771Google Scholar
  16. 16.
    Schlag G, Krösl P, Zimpfer M (1985) Wertigkeit myokardialer Lastfaktoren für die Kardiodynamik in Inhalationsanaesthesi. Proceedings 5. Ludwig Boltzmann-Symposium. (in press)Google Scholar
  17. 17.
    Van Ackern K, Adler M, Brückner UB, Buell U, Haller M, Ragaller M, Raithel E, Woeller W (1984) Effects of isoflurane on myocardial ischemia in dogs: regional changes of blood flow, contractility, and metabolism. Anesthesiology 61: A32CrossRefGoogle Scholar
  18. 18.
    Vatner SF (1980) Correlation between acute reductions in myocardial blood flow and function in conscious dogs. Circ Res 47: 201–207PubMedGoogle Scholar
  19. 19.
    Vatner SF, Boettcher DH (1978) Regulation of cardiac output by stroke volume and heart rate in conscious dogs. Circ Res 42: 557–561PubMedGoogle Scholar
  20. 20.
    Vatner SF, Franklin D, Van Citters RL (1970) Simultaneous comparison and calibration of the Doppler and electromagnetic flowmeters. J Appl Physiol 29: 907PubMedGoogle Scholar
  21. 21.
    Vatner SF, Franklin D, Higgins CB, White S, Van Citters RL (1973) Calibration of the ultrasonic Doppler flowmeter in situ. In: McCutcheon EP (ed) Chronically implanted cardiovascular instru-mentation. Academic, New York, p 63Google Scholar
  22. 22.
    Vatner SF, Pagani M, Manders WT, Pasipoularides AD (1980) Alpha adrenergic vasoconstriction and nitroglycerin vasodilatation of large coronary arteries in the conscious dog. J Clin Invest 65: 5–14PubMedCrossRefGoogle Scholar
  23. 23.
    Vatner SF, Zimpfer M (1981) Bainbridge reflex in conscious unrestrained, and tranquilized baboons. Am J Physiol 240: H164–H167PubMedGoogle Scholar
  24. 24.
    Vogel H, Günther H, Harrison DK, Kessler M, Peter K (1984) The indluence of isoflurane and enflurane on tissue oxygenation and micrcirculation of the dog myocardium. Anesthesiology 61: A5CrossRefGoogle Scholar
  25. 25.
    Williams JF, Sonnenblick EH, Braumwald E (1965) Determinants of arterial contractile force in the intact heart. J Physiol 209: 1061–1068Google Scholar
  26. 26.
    Zimpfer M, Vatner SF (1981) Effects of acute increases in left ventricular preload on indices of myocardial function in conscious, unrestrained and intact, tranquilized baboons. J Clin Invest 67: 430–438PubMedCrossRefGoogle Scholar
  27. 27.
    Zimpfer M, Sit SP, Vatner SF (1981) Effects of anesthesia on the carotid chemoreceptor reflex. Circ Res 48: 400–406PubMedGoogle Scholar
  28. 28.
    Zimpfer M, Gilly H, Krösl P, Schlag G, Steinbreithner K (1983) Importance of myocardial loading conditions in determining the effects of enflurane on left ventricular function in the intact and isolated canine heart. Anesthesiology 58: 159–169PubMedCrossRefGoogle Scholar
  29. 29.
    Zimpfer M, Gilly H, Mayer N (1984) Kardiodynamik chronisch instrumentierter Hund im Wach-zustand und in Isofluran-Narkose. Isofluran, experimentelle und klinische Aspekt. Excerpta Medica: 45–55Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. Zimpfer
  • N. Mayer
  • H. Gilly
  • E. Maurer
  • K. Steinbereithner

There are no affiliations available

Personalised recommendations