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Aspects of the Effects of Enflurane on Cardiovascular Control

  • D. Lundberg
  • B. Biber
  • B.-Å. Henriksson
  • J. Martner
  • J. Pontén
Conference paper
  • 31 Downloads
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)

Abstract

In the process of evaluation of new inhalational anesthetics the assessment of cardiovascular effects is important especially in the light of the increasing frequency of operations on patients with serious cardiovascular disorders. Like most other inhalational anesthetics enflurane reduces systemic arterial pressure probably both by causing cardiac depression and decreased peripheral vascular resistance. The mechanisms by which enflurane decreases vascular resistance, however, are not fully understood. The vascular resistance may be diminished by decreased sympathetic vasoconstrictor tone elicited at central and/or peripheral sites of the autonomic nervous system, by interference with local regulatory mechanisms of the peripheral vascular bed or by direct effects on the vascular smooth muscles. For references, see [1, 2]. The lack of detailed knowledge can be explained by the fact that the cardiovascular regulatory system is very complex and composed by a row of interrelated mechanisms with which drugs may interact simultaneously and which therefore are technically very difficult to study.

Keywords

Peripheral Vascular Resistance Electric Field Stimulation Systemic Arterial Pressure Jejunal Segment Vasomotor Centre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hickey RF, Eger EJ (1981) Circulatory pharmacology of inhaled anesthetics. In: Miller RD (ed) Anesthesia. Churchill Livingstone, New York, pp 331–348Google Scholar
  2. 2.
    Henriksson BÅ (1984) Effects of enflurane on sympathetic and local cardiovascular control. An experimental study. Thesis, University of Göteborg, SwedenGoogle Scholar
  3. 3.
    Henriksson BÅ Biber B, Martner J, Pontén J and Werner O (1985) Cardiovascular studies during controlled baroreflex activation in the dog: 1. Effects of enflurane. Acta Anaesthesiol Scand 29: 90–94PubMedCrossRefGoogle Scholar
  4. 4.
    Henriksson BÅ, Biber B, Lundberg D, Martner J, Ponten J and Sonander H (1985) Intestinal vascular effects of inhaled and locally administered enflurane in the cat. Acta Anaesthesiol Scand 29: 294–299PubMedCrossRefGoogle Scholar
  5. 5.
    Henriksson BÅ, Biber B, Lundberg D, Martner J, Nilsson H and Ponten J (1985) Vasodilator responses to enflurane in the small intestine. Acta Anaesthesiol Scand 29: 287–293PubMedCrossRefGoogle Scholar
  6. 6.
    Göthert M, Kennerknecht E, and Thielecke G (1976) Inhibition of receptor-mediated noradrenaline release from the sympathetic nerves of the isolated rabbit heart by anaesthetics and alcohol in proportion to their hydrophobic property. Naunyn-Schmiedeberg’s Arch Pharmacol 292: 145PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • D. Lundberg
  • B. Biber
  • B.-Å. Henriksson
  • J. Martner
  • J. Pontén

There are no affiliations available

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