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Inhalation Anesthetics and Malignant Hyperthermia

  • J. Riemer
Conference paper
  • 32 Downloads
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)

Abstract

Malignant hyperthermia (MH) is a pharmacogenetic disease. A combination of two conditions is required for it to manifest itself: a genetic predisposition and an effective trigger substance, making the latent defect evident [3]. In the pathogenesis of MH today it is generally accepted that a sudden and uncontrolled increase of free Ca-ion concentration in the muscle cell is the decisive trigger mechanism from which ultimately clinical symptoms of an acute MH crisis are derived [5]. So far the background for this flooding of myoplasma with free Ca-ions, details of the trigger mechanism, and the properties of the specific trigger compounds are not exactly known.

Keywords

Sarcoplasmatic Reticulum Malignant Hyperthermia Malignant Hyperthermia Inhalation Anesthetic Transversal Tubule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. Riemer

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