Inhalation Anesthetics and Malignant Hyperthermia

  • J. Riemer
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 185)


Malignant hyperthermia (MH) is a pharmacogenetic disease. A combination of two conditions is required for it to manifest itself: a genetic predisposition and an effective trigger substance, making the latent defect evident [3]. In the pathogenesis of MH today it is generally accepted that a sudden and uncontrolled increase of free Ca-ion concentration in the muscle cell is the decisive trigger mechanism from which ultimately clinical symptoms of an acute MH crisis are derived [5]. So far the background for this flooding of myoplasma with free Ca-ions, details of the trigger mechanism, and the properties of the specific trigger compounds are not exactly known.


Sarcoplasmatic Reticulum Malignant Hyperthermia Malignant Hyperthermia Inhalation Anesthetic Transversal Tubule 
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© Springer-Verlag Berlin Heidelberg 1987

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  • J. Riemer

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