Isoflurane pp 32-36 | Cite as

Toxicity of Repeat Isoflurane? A Preliminary Report

  • C. E. Blogg
  • J. W. Sear
  • J. Dunnet
  • D. Brighouse
Part of the Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin book series (A+I, volume 182)


Hepatitis related to halothane has been found to follow about 1 in 35000 halothane anaesthesia [1]. One of the most important factors in unexplained hepatitis following halothane (UHFH) is repeated exposure to halothane within a short period, and the results of the investigation of a prospective series of patients undergoing radium implantation in Oxford in 1973–1974 appeared to confirm the association [2]. Subsequently, there has been extreme reluctance to repeat the use of halothane for anaesthesia within a few weeks (especially in middle-aged, obese women being treated for carcinoma of the cervix), despite other reports which show lack of adverse hepatic effects [3, 4].


Liver Function Test Isoflurane Anaesthesia Abnormal Liver Function Test Isoflurane Group Halothane Hepatitis 
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  1. 1.
    Stock GL, Strunin L (1985) Unexplained hepatitis following halothane. Anesthesiology 63:424– 439Google Scholar
  2. 2.
    Trowell J, Peto R, Smith AC (1975) Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium. Lancet 1: 821–831PubMedGoogle Scholar
  3. 3.
    Allen PJ, Downing JW (1977) A prospective study of hepatocellular function after repeated exposures to halothane or enflurane in women undergoing radium therapy for cervical cancer. Br J Anaesth 49: 1035–1039PubMedCrossRefGoogle Scholar
  4. 4.
    Wark HJ, Clifton B, Bookallil MJ (1979) Halothane hepatitis revisited in women undergoing treatment of carcinoma of the cervix. Br J Anaesth 51: 763–766PubMedCrossRefGoogle Scholar
  5. 5.
    Blogg CE, Sear JW (1985) Isoflurane: Metabolism, hepatic function and toxicity. In: Bennetts FE (ed) Isoflurane. The current position. Proceedings of a symposium. Medical Education Servicesm Oxford, England, pp 29–33Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • C. E. Blogg
  • J. W. Sear
  • J. Dunnet
  • D. Brighouse

There are no affiliations available

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