Advertisement

Isoflurane pp 32-36 | Cite as

Toxicity of Repeat Isoflurane? A Preliminary Report

  • C. E. Blogg
  • J. W. Sear
  • J. Dunnet
  • D. Brighouse
Part of the Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin book series (A+I, volume 182)

Abstract

Hepatitis related to halothane has been found to follow about 1 in 35000 halothane anaesthesia [1]. One of the most important factors in unexplained hepatitis following halothane (UHFH) is repeated exposure to halothane within a short period, and the results of the investigation of a prospective series of patients undergoing radium implantation in Oxford in 1973–1974 appeared to confirm the association [2]. Subsequently, there has been extreme reluctance to repeat the use of halothane for anaesthesia within a few weeks (especially in middle-aged, obese women being treated for carcinoma of the cervix), despite other reports which show lack of adverse hepatic effects [3, 4].

Keywords

Liver Function Test Isoflurane Anaesthesia Abnormal Liver Function Test Isoflurane Group Halothane Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Stock GL, Strunin L (1985) Unexplained hepatitis following halothane. Anesthesiology 63:424– 439Google Scholar
  2. 2.
    Trowell J, Peto R, Smith AC (1975) Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium. Lancet 1: 821–831PubMedGoogle Scholar
  3. 3.
    Allen PJ, Downing JW (1977) A prospective study of hepatocellular function after repeated exposures to halothane or enflurane in women undergoing radium therapy for cervical cancer. Br J Anaesth 49: 1035–1039PubMedCrossRefGoogle Scholar
  4. 4.
    Wark HJ, Clifton B, Bookallil MJ (1979) Halothane hepatitis revisited in women undergoing treatment of carcinoma of the cervix. Br J Anaesth 51: 763–766PubMedCrossRefGoogle Scholar
  5. 5.
    Blogg CE, Sear JW (1985) Isoflurane: Metabolism, hepatic function and toxicity. In: Bennetts FE (ed) Isoflurane. The current position. Proceedings of a symposium. Medical Education Servicesm Oxford, England, pp 29–33Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • C. E. Blogg
  • J. W. Sear
  • J. Dunnet
  • D. Brighouse

There are no affiliations available

Personalised recommendations