Plasma Levels of Stress Hormones Under Isoflurane Anaesthesia in Comparison to Other Anaesthetic Techniques
An anaesthestic agent can be evaluated not only with regard to its influence on homeostasis as such but also in terms of its ability to protect the organism from surgical stress. Responses to surgical trauma are largely mediated through the autonomic nervous system and adrenal medulla and are, therefore, reflected by increases in heart rate, blood pressure, and concentrations of stress-associated substances in the circulation during and after surgery. Increases in Cortisol and catecholamines are considered to be reliable indicators of surgical trauma and manifestations of the physiological response to stress [21, 25]. It has also been suggested that beta-endorphins play a definite role in the biologic response to stress as well as in the endogenous mode of pain perception .
KeywordsCortisol Catecholamine Diazepam Fentanyl Midazolam
Unable to display preview. Download preview PDF.
- 11.Glisson SN, Balasaraswathi K (1981) Isoflurane sympathoadrenal responses in man compared to enflurane and halothane. Anesthesiology 55 (Suppl.): A296Google Scholar
- 17.Johnson GA, Peuler J, Baker CA (1977) Plasma catecholamine concentrations in normal subjects. Curr Ther Res 21: 898–902Google Scholar
- 25.Selye H (1976) Stress in health and disease. Butterworths, LondonGoogle Scholar