Abstract
Isoflurane is a direct myocardial depressant but, when compared with halothane and enflurane it provides improved maintenance of cardiac output [1], Isoflurane causes a dose-related decrease in systemic vascular resistance with peripheral vasodilation, a reduction in pre-load and after-load and in myocardial work and oxygen consumption [2]. Dose-dependent arterial hypotension [3] is the main clinical disadvantage, particularly in the presence of coronary artery disease where there is a limit of tolerance to arterial hypotension. Reiz and colleagues [4] have postulated that, in the presence of coronary artery occlusion, isoflurane-induced coronary artery vasodilation leads to the redistribution of myocardial blood flow and a “steal” phenomenon which may cause ischaemic damage in the region of the myocardium supplied by the stenosed artery. This comparative study was designed to investigate the clinical implications of this theory.
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© 1986 Springer-Verlag Berlin Heidelberg
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Florence, A.M. (1986). Isoflurane in Patients with Ischaemic Heart Disease. In: Lawin, P., Van Aken, H., Puchstein, C. (eds) Isoflurane. Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71230-2_34
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DOI: https://doi.org/10.1007/978-3-642-71230-2_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16574-3
Online ISBN: 978-3-642-71230-2
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