Isoflurane pp 154-168 | Cite as

Evaluation of the Potential of Isoflurane vs Dipyridamole to Aggravate Myocardial Ischemia by Causing Coronary Vasodilatation

  • M. Zimpfer
  • N. Mayer
  • E. Maurer
  • K. Steinbereithner
Conference paper
Part of the Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin book series (A+I, volume 182)


Isoflurane has been contended to be a “powerful” coronary vasodilator contributing to myocardial ischemia by causing a coronary steal mechanism [19, 20]. Although harmful effects on ischemic myocardium have been observed with intravenous anesthesia techniques as well [3, 6, 24], some recent studies in experimental animals [8, 9, 12] as well as clinical investigations [17–21] point towards a particular potential of inhalation anesthesia to aggravate myocardial ischemia, while others do not [3, 4, 16, 29, 41]. In this paper we describe the overall effects of isoflurane on the cardiovascular system and the simultaneous changes of coronary blood flow in comparison with the vascular and myocardial effects of the potent coronary vasodilator dipyridamole. As the most important effect of myocardial ischemia is its impact on myocardial function, we review the influence of isoflurane on the contractile function of both normal and chronically ischemic myocardium.


Myocardial Ischemia Myocardial Blood Flow Coronary Blood Flow Volatile Anesthetic Reactive Hyperemia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • M. Zimpfer
  • N. Mayer
  • E. Maurer
  • K. Steinbereithner

There are no affiliations available

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