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Isoflurane pp 100-101 | Cite as

Cerebrovascular and Metabolic Effects of Isoflurane and Halothane: A Preliminary Report

  • K. Messeter
  • L. Algotsson
  • C.-H Nordström
  • E. Ryding
Conference paper
Part of the Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin book series (A+I, volume 182)

Abstract

Cerebrovascular and metabolic effects of volatile anaesthetics, barbiturates and narcotics have been extensively studied in animals and humans (Smith 1975). Although most of these agents cause a dose-dependent decrease in cerebral oxygen consumption, the cerebrovascular properties vary considerably. In contrast to barbiturates, most volatile anaesthetics increase CBF, usually in a dose-dependent manner. Since cerebral vasodilatation caused by these agents leads to an increase in cerebral blood volume, administration of volatile anaesthetics to patients with intracranial space occupying lesions are considered dangerous, although the risk of increased intracranial pressure can usually be controlled by means of adequate hyperventilation. The introduction of isoflurane has caused a great deal of interest, since it has been suggested that the cerebral vasodilatory properties in humans are less pronounced than those of halothane (Murphy et al. 1974; Eintrei et al. 1985). Reports suggesting that cerebral metabolic effects of isoflurane differ from halothane are based on observations in animals (Cucchiara et al. 1974; Newberg et al. 1983; Todd et al. 1984). Mean hemispheric blood flow and cerebral oxygen consumption were therefore studied in humans during isoflurane and halothane anaesthesia.

Keywords

Cerebral Blood Volume Volatile Anaesthetic Halothane Anaesthesia Brain Blood Flow Intracranial Space 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Cucchiara RF, Theye RA, Michenfelder JD (1974) The effects of isoflurane on canine cerebral metabolism and blood flow. Anesthesiology 40 (6): 571–574PubMedCrossRefGoogle Scholar
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  3. Murphy FL, Kennwell EM, Johnstone RE et al. (1974) The effects of enflurane, isoflurane, and halothane on cerebral blood flow and metabolism in man. Abstracts of scientific papers, American society of anesthesiologists, annual meeting, pp 61–62Google Scholar
  4. Newberg LA, Milde JH, Michenfelder JD (1983) The cerebral metabolic effects of isoflurane at above concentrations that suppress cortical electrical activity. Anesthesiology 59: 23–28PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. Messeter
  • L. Algotsson
  • C.-H Nordström
  • E. Ryding

There are no affiliations available

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