Abstract
The most striking feature of isoflurane, at least as far as the cerebral circulation is concerned, is the biphasic nature of the changes in cerebrovascular resistance which accompany its administration (van Aken et al. 1986). Low concentrations (less than 0.5 vol%) have been shown to induce vasoconstriction [cerebral blood flow (CBF) decreases], whereas the administration of higher concentrations (at least up to around 1.5 vol%) is associated with dilatation of the cerebral vessels.
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© 1986 Springer-Verlag Berlin Heidelberg
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Fitch, W., Graham, D.I., Van Aken, H. (1986). Changes in Regional (Local) Cerebral Blood Flow During Isoflurane-induced Hypotension. In: Lawin, P., Van Aken, H., Puchstein, C. (eds) Isoflurane. Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71230-2_17
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DOI: https://doi.org/10.1007/978-3-642-71230-2_17
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