Abstract
This discussion is devoted to the broad and complex subject of possible interactions of volatile (inhalation) anesthetics with other drugs used in anesthesia. It is impossible to give a detailed review of this theme (Gnoheim 1971; Ravolins 1978) in the space allotted to me, and therefore I shall describe the basic principles involved, viewed from a unitary point of view; this will enable one to see the subject in a wide perspective. In order to do this I have chosen to follow both inhalation agents and interacting drugs from their port of entry to the places in the body where they meet and to consider what takes place in the process.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bloor BC, Flacke W (1982) Reduction in halothane anesthetic requirement by clonidine, an alpha-adrenergic agonist. Anesth Analg 61: 741–745
Crul JF, Booij LHDJ (1984) Brochure, inhalational anesthesia and muscle relaxation. Brochure Ana-quest
Cullen BF, Miller MG (1979) Drug interactions and anesthesia: a review. Anesth Analg 58: 413–423
Dodson BA, Miller KW (1985) Evidence of dual mechanism in the anesthetic action of an opioid peptide. Anesthesiology 62: 615
Donati F, Bevan DR (1983) Potentiation of succinylcholine phase II block with isoflurane. Anesthesiology 58: 552–555
Eger EJII (1974) Anesthetic uptake and action. Williams and Wilkins, Baltimore
Fischer KJ, Rice SA (1983) Halothane inhibits metabolism of enflurane in Fischer 344 rats. Anesthesiology 59: 417–420
Forbes AR, Cohen NH, Eger E II (1979) Pancuronium reduces halothane requirement in man. Anesth Analg 58: 497
Gnoheim MM (1971) Drug interaction in anesthesia, a review. Can Anaesth Soc J 18: 353–375
Halsey MJ, Wardley-Smith B (1975) Pressure reversal of narcosis produced by anaesthetics, narcotics and tranquilisers. Nature 257: 811
Hecker BR et al. (1983) The decrease of the minimum alveolar anesthetic concentration produced by sufentanil in rats. Anesth Analg 62: 987–990
Kissin J, Kerr CR, Smith LR (1984) Morphine-halothane interaction in rats. Anesthesiology 60:553–561
Melvin MA et al. (1982) Induction of anesthesia with midazolam decreases halothane MAC in humans. Anesthesiology 57 (3): 239–241
Miller RD (1981) Anesthesia, vol 1. Churchill, Livingstone
Miller RD, Agoston S, v.d. Pol F, Booij LHDJ, Crul JF (1970) Effect of different anesthetics on the parmacokinetics an pharmacodynamics of pancuronium in the cat. Acta Anaesth Scand 23: 285
Polc P, Bonetti EP, Schaffner R, Haefely W (1982) A three state model of the benzodiazepines antagonist R15-1788 benzodiazepine tranquilisers, beta-carbolines and phenobarbitone. Naunyn- Schmiedebergs Arch Pharmacol (with permission)321–260
Priestley P (1981) Serotonin and anesthesia. Aana J 49: 511–515
Ravolins MD (1978) Drug interactions and anaesthesia. Br J Anaesth 50: 689–693
Siegers CP, Mackenroth T, Younes M (1981) Inhibition and acceleration of the metabolism of enflurane and methoxyflurane in rats. Anaesthesist 30: 83–87
Singer SJ, Micholson GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175: 720
Takagi T et al. (1983) Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. Pharmacol Biochem Behav 18 [Suppl l]: 461–465
Trudell J (1977) An unitary theory of anesthesia based on lateral phase separations in nerve membranes. Anesthesiology 46: 5–10
Waser PG (1985) Morphology and molecular function of the cholinergic synapse. Eur J Anesth 2: 105–119
Wood M, Wood AJJ (1984) Contrasting effects of halothane, isoflurane and enflurane on in vivo drug metabolism in the rat. Anesth Analg 63: 709–714
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Crul, J.F. (1986). Interactions of Volatile Anesthetics and Other Drugs Used in Clinical Practice. In: Lawin, P., Van Aken, H., Puchstein, C. (eds) Isoflurane. Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71230-2_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-71230-2_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16574-3
Online ISBN: 978-3-642-71230-2
eBook Packages: Springer Book Archive