Isoflurane pp 56-66 | Cite as

Interactions of Volatile Anesthetics and Other Drugs Used in Clinical Practice

  • J. F. Crul
Conference paper
Part of the Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin book series (A+I, volume 182)

Abstract

This discussion is devoted to the broad and complex subject of possible interactions of volatile (inhalation) anesthetics with other drugs used in anesthesia. It is impossible to give a detailed review of this theme (Gnoheim 1971; Ravolins 1978) in the space allotted to me, and therefore I shall describe the basic principles involved, viewed from a unitary point of view; this will enable one to see the subject in a wide perspective. In order to do this I have chosen to follow both inhalation agents and interacting drugs from their port of entry to the places in the body where they meet and to consider what takes place in the process.

Keywords

Midazolam Isoflurane Halothane Clonidine Barbiturate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bloor BC, Flacke W (1982) Reduction in halothane anesthetic requirement by clonidine, an alpha-adrenergic agonist. Anesth Analg 61: 741–745PubMedCrossRefGoogle Scholar
  2. Crul JF, Booij LHDJ (1984) Brochure, inhalational anesthesia and muscle relaxation. Brochure Ana-questGoogle Scholar
  3. Cullen BF, Miller MG (1979) Drug interactions and anesthesia: a review. Anesth Analg 58: 413–423PubMedGoogle Scholar
  4. Dodson BA, Miller KW (1985) Evidence of dual mechanism in the anesthetic action of an opioid peptide. Anesthesiology 62: 615PubMedCrossRefGoogle Scholar
  5. Donati F, Bevan DR (1983) Potentiation of succinylcholine phase II block with isoflurane. Anesthesiology 58: 552–555PubMedCrossRefGoogle Scholar
  6. Eger EJII (1974) Anesthetic uptake and action. Williams and Wilkins, BaltimoreGoogle Scholar
  7. Fischer KJ, Rice SA (1983) Halothane inhibits metabolism of enflurane in Fischer 344 rats. Anesthesiology 59: 417–420CrossRefGoogle Scholar
  8. Forbes AR, Cohen NH, Eger E II (1979) Pancuronium reduces halothane requirement in man. Anesth Analg 58: 497PubMedGoogle Scholar
  9. Gnoheim MM (1971) Drug interaction in anesthesia, a review. Can Anaesth Soc J 18: 353–375CrossRefGoogle Scholar
  10. Halsey MJ, Wardley-Smith B (1975) Pressure reversal of narcosis produced by anaesthetics, narcotics and tranquilisers. Nature 257: 811PubMedCrossRefGoogle Scholar
  11. Hecker BR et al. (1983) The decrease of the minimum alveolar anesthetic concentration produced by sufentanil in rats. Anesth Analg 62: 987–990PubMedCrossRefGoogle Scholar
  12. Kissin J, Kerr CR, Smith LR (1984) Morphine-halothane interaction in rats. Anesthesiology 60:553–561PubMedCrossRefGoogle Scholar
  13. Melvin MA et al. (1982) Induction of anesthesia with midazolam decreases halothane MAC in humans. Anesthesiology 57 (3): 239–241CrossRefGoogle Scholar
  14. Miller RD (1981) Anesthesia, vol 1. Churchill, LivingstoneGoogle Scholar
  15. Miller RD, Agoston S, v.d. Pol F, Booij LHDJ, Crul JF (1970) Effect of different anesthetics on the parmacokinetics an pharmacodynamics of pancuronium in the cat. Acta Anaesth Scand 23: 285CrossRefGoogle Scholar
  16. Polc P, Bonetti EP, Schaffner R, Haefely W (1982) A three state model of the benzodiazepines antagonist R15-1788 benzodiazepine tranquilisers, beta-carbolines and phenobarbitone. Naunyn- Schmiedebergs Arch Pharmacol (with permission)321–260Google Scholar
  17. Priestley P (1981) Serotonin and anesthesia. Aana J 49: 511–515PubMedGoogle Scholar
  18. Ravolins MD (1978) Drug interactions and anaesthesia. Br J Anaesth 50: 689–693CrossRefGoogle Scholar
  19. Siegers CP, Mackenroth T, Younes M (1981) Inhibition and acceleration of the metabolism of enflurane and methoxyflurane in rats. Anaesthesist 30: 83–87PubMedGoogle Scholar
  20. Singer SJ, Micholson GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175: 720PubMedCrossRefGoogle Scholar
  21. Takagi T et al. (1983) Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. Pharmacol Biochem Behav 18 [Suppl l]: 461–465PubMedCrossRefGoogle Scholar
  22. Trudell J (1977) An unitary theory of anesthesia based on lateral phase separations in nerve membranes. Anesthesiology 46: 5–10PubMedCrossRefGoogle Scholar
  23. Waser PG (1985) Morphology and molecular function of the cholinergic synapse. Eur J Anesth 2: 105–119Google Scholar
  24. Wood M, Wood AJJ (1984) Contrasting effects of halothane, isoflurane and enflurane on in vivo drug metabolism in the rat. Anesth Analg 63: 709–714PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. F. Crul

There are no affiliations available

Personalised recommendations