Passive and Active Anti-Hepatitis B Immunization of Children with Hematological Malignancies

  • J. Bogusławska-Jaworska
  • E. Gorczyńska
  • H. Seyfried
  • A. Gładysz
  • M. Zalewska
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


The risk of hepatitis B virus (HBV) infection is evidently higher in children with hematological malignancies than in the general population [1–4] Unlike healthy children, a high proportion of those receiving chemotherapy for leukemia and lymphoma who are infected with HBV become chronic carriers [4]. Most of them remain highly contagious throughout the cytostatic therapy. Their infectivity is associated with a frequent occurrence of HBV antigen in their tissues and body fluids and its excretion in saliva and urine [5]. Controlling the HBV infection chain is a difficult problem. The passive and active specific immunization may provide the solution. In this paper we report results of the study on the efficacy of the two different immunization formulae which we used during the epidemic in 1982–1985.


Acute Leukemia Acute Lymphatic Leukemia Cytostatic Therapy Chronic HBsAg Carrier Renal Transplant Recip 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. Bogusławska-Jaworska
    • 1
    • 2
    • 3
  • E. Gorczyńska
  • H. Seyfried
  • A. Gładysz
  • M. Zalewska
  1. 1.Department of Pediatric HematologyMedical SchoolWroclawPoland
  2. 2.Department of SerologyInstitute of HematologyWarsawPoland
  3. 3.Department of Infections DiseasesMedical SchoolWroclawPoland

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