Hyperdiploid Childhood Acute Lymphocytic Leukemia: Cellular Properties and Prognostic Implications

  • L. A. Smets
  • H. Behrendt
  • G. de Vaan
  • K. Hählen
  • F. C. de Waal
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


Alterations in modal DNA per cell content or numerical increases in chromosome number are frequently observed in childhood acute lymphocytic leukemia (ALL). In most instances, these karyotypic changes involve a 20% increase in modal DNA content accompanied by a chromosome number of n> 50. This ALL subtype is usually referred to as hyperdiploid ALL (HD-ALL). Whereas in most malignant conditions aneuploidy of either DNA content or chromosome number is a sign of poor prognosis, several studies have assigned a favorable prognosis to HD-ALL [4, 6, 8, 9]. However, negative [3] or even contrary conclusions [5] as to the existence of such a correlation have also been reported.


Acute Myeloid Leukemia Acute Lymphocytic Leukemia White Blood Cell Count Childhood Acute Lymphocytic Leukemia Maturation Index 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. A. Smets
    • 1
  • H. Behrendt
    • 2
  • G. de Vaan
    • 3
  • K. Hählen
    • 4
  • F. C. de Waal
    • 5
  1. 1.Division of Experimental TherapyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Emma KinderziekenhuisAmsterdamThe Netherlands
  3. 3.St. Radboud ZiekenhuisNijmegenThe Netherlands
  4. 4.Sophia KinderziekenhuisRotterdamThe Netherlands
  5. 5.Academic HospitalFree UniversityAmsterdamThe Netherlands

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