Advertisement

Hyperdiploid Childhood Acute Lymphocytic Leukemia: Cellular Properties and Prognostic Implications

  • L. A. Smets
  • H. Behrendt
  • G. de Vaan
  • K. Hählen
  • F. C. de Waal
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)

Abstract

Alterations in modal DNA per cell content or numerical increases in chromosome number are frequently observed in childhood acute lymphocytic leukemia (ALL). In most instances, these karyotypic changes involve a 20% increase in modal DNA content accompanied by a chromosome number of n> 50. This ALL subtype is usually referred to as hyperdiploid ALL (HD-ALL). Whereas in most malignant conditions aneuploidy of either DNA content or chromosome number is a sign of poor prognosis, several studies have assigned a favorable prognosis to HD-ALL [4, 6, 8, 9]. However, negative [3] or even contrary conclusions [5] as to the existence of such a correlation have also been reported.

Keywords

Acute Myeloid Leukemia Acute Lymphocytic Leukemia White Blood Cell Count Childhood Acute Lymphocytic Leukemia Maturation Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Goldie JH, Coldman AJ (1979) A mathematic model for relating the drug sensitivity of tumors to the spontaneous mutation rate. Cancer Treat Rep 63:1727–1733Google Scholar
  2. 2.
    Frei E III, Sallan SE (1978) Acute lymphoblastic leukemia treatment. Cancer 42:828–838Google Scholar
  3. 3.
    Hiddeman W, Ritter J, Worman B, Budde M, Creutzig U, Schellong G, Büchner Th, Riehm H (1985) DNS-Aneuploidie bei Kindern mit akuten Leukämien I. Inzidenz and klinische Bedeutung im Rahmen der BFM-Studien. Klin Padiat 197:215–220CrossRefGoogle Scholar
  4. 4.
    Look T, Roberson PK, Williams DL, Rivera G, Bowman WP, Pui CH, Ochs J, Abromowitch M, Kalwinsky D, Dahl GV, George S, Murphy SB (1985) Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia. Blood 65:1079–1086Google Scholar
  5. 5.
    Morse HG, Odom LF, Tubergen D, Hays T, Blake M, Robinson A (1983) Prognosis in acute lymphoblastic leukemia of childhood as determined by cytogenetic studies at diagnosis. Med Pediatr Oncol 11:310–318CrossRefGoogle Scholar
  6. 6.
    Seeker-Walker LM (1984) The prognostic implications of chromosomal findings in acute lymphoblastic leukemia. Cancer Genet Cytogenet 11:233–248CrossRefGoogle Scholar
  7. 7.
    Smets LA, Bout B, Brouwer M, Tulp A (1983) Cytotoxic effects of dexamethasone restricted to noncycling, early G1-phase cells of L1210 leukemia. J Cell Physiol 116:397–403CrossRefGoogle Scholar
  8. 8.
    Smets LA, Slater RM, Behrendt H, Van’t Veer MB, Homan-Blok J (1985) Phenotypic and karyotypic properties of hyperdiploid acute lymphoblastic leukaemia of childhood. Br J Haematol 61:113–123CrossRefGoogle Scholar
  9. 9.
    Williams DL, Tsiatis A, Brodeur GM, Look AT, Melvin SL, Bowman WP, Kalwinsky DK, Rivera G, Dahl GV (1982) Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. Blood 60:864–871Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. A. Smets
    • 1
  • H. Behrendt
    • 2
  • G. de Vaan
    • 3
  • K. Hählen
    • 4
  • F. C. de Waal
    • 5
  1. 1.Division of Experimental TherapyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Emma KinderziekenhuisAmsterdamThe Netherlands
  3. 3.St. Radboud ZiekenhuisNijmegenThe Netherlands
  4. 4.Sophia KinderziekenhuisRotterdamThe Netherlands
  5. 5.Academic HospitalFree UniversityAmsterdamThe Netherlands

Personalised recommendations