Hyperdiploid Childhood Acute Lymphocytic Leukemia: Cellular Properties and Prognostic Implications
Alterations in modal DNA per cell content or numerical increases in chromosome number are frequently observed in childhood acute lymphocytic leukemia (ALL). In most instances, these karyotypic changes involve a 20% increase in modal DNA content accompanied by a chromosome number of n> 50. This ALL subtype is usually referred to as hyperdiploid ALL (HD-ALL). Whereas in most malignant conditions aneuploidy of either DNA content or chromosome number is a sign of poor prognosis, several studies have assigned a favorable prognosis to HD-ALL [4, 6, 8, 9]. However, negative  or even contrary conclusions  as to the existence of such a correlation have also been reported.
KeywordsAcute Myeloid Leukemia Acute Lymphocytic Leukemia White Blood Cell Count Childhood Acute Lymphocytic Leukemia Maturation Index
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