Results of Acute Lymphoblastic Leukemia Therapy in Childhood with a Modified BFM Protocol in a Multicenter Study in the German Democratic Republic

  • F. Zintl
  • W. Plenert
  • H. Malke
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)

Abstract

Considerable progress in the treatment of acute lymphoblastic leukemia (ALL) has been made in the last 30 years, particularly childhood ALL. The basis of this progress has been modern multidisciplinary management and controlled clinical trials. The most important problem in the therapy of ALL in childhood is the relapse of leukemia. From 1978 to 1981, we did not succeed in raising the relapse-free survival of children with high-risk factors above 30% [1] with the LSA2L2 protocol [2]. In a study carried out from 1970 to 1976 [3], it was shown that the intensification and prolongation of the remission-induction phase resulted in a higher percentage of relapse-free long-term survival. We adopted the principles of the BFM protocol in 1981 and started the controlled and randomized multicentric ALL study VII/81.

Keywords

Lymphoma Leukemia Oncol Stratification Methotrexate 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • F. Zintl
    • 1
  • W. Plenert
    • 1
  • H. Malke
    • 1
  1. 1.Department of Pediatrics and GDR Working Group for Pediatric Hematology and OncologyUniversity of JenaJenaGerman Democratic Republic

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