Early Intensification Therapy in High-Risk Childhood Acute Lymphocytic Leukemia: Lack of Benefit from High-Dose Methotrexate

  • G. E. Janka
  • K. Winkler
  • H. Juergens
  • U. Goebel
  • COALL Study Groups
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


The prognosis for acute lymphoblastic leukemia (ALL) in childhood has improved considerably in the last two decades. Intensive chemotherapy soon after diagnosis has made a major contribution to this success [3, 12, 14], especially in patients with adverse prognostic factors [6]. In COALL-80, a cooperative West German treatment study for ALL, high-risk patients received intensive combination chemotherapy after a modification of the West Berlin protocol BFM 79/81 [7]. In the subsequent study, COALL-82, high-dose methotrexate was added to the intensive phase regimen. The results of both studies, which included 95 high-risk patients, are reported in this paper.


AAAA AAAA Intensive Phase Reinduction Therapy Methotrexate Infusion Acute Undifferentiated Leukemia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • G. E. Janka
    • 1
  • K. Winkler
    • 1
  • H. Juergens
    • 2
  • U. Goebel
    • 2
  • COALL Study Groups
  1. 1.Department of Hematology and OncologyChildren’s Hospital University of HamburgGermany
  2. 2.Department of Hematology and OncologyChildren’s Hospital University of DüsseldorfFederal Republic of Germany

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