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Early Intensification Therapy in High-Risk Childhood Acute Lymphocytic Leukemia: Lack of Benefit from High-Dose Methotrexate

  • Conference paper
Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 30))

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Abstract

The prognosis for acute lymphoblastic leukemia (ALL) in childhood has improved considerably in the last two decades. Intensive chemotherapy soon after diagnosis has made a major contribution to this success [3, 12, 14], especially in patients with adverse prognostic factors [6]. In COALL-80, a cooperative West German treatment study for ALL, high-risk patients received intensive combination chemotherapy after a modification of the West Berlin protocol BFM 79/81 [7]. In the subsequent study, COALL-82, high-dose methotrexate was added to the intensive phase regimen. The results of both studies, which included 95 high-risk patients, are reported in this paper.

Supported by the Werner-Otto-Stiftung and the Tumor Center, Hamburg.

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Author information

Authors and Affiliations

  1. Department of Hematology and Oncology, Children’s Hospital University of Hamburg, Germany

    G. E. Janka & K. Winkler

  2. Department of Hematology and Oncology, Children’s Hospital University of Düsseldorf, Federal Republic of Germany

    H. Juergens & U. Goebel

Authors
  1. G. E. Janka
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  2. K. Winkler
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  3. H. Juergens
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  4. U. Goebel
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COALL Study Groups

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Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann , D. Urbanitz  & J. Ritter , , ,  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Janka, G.E., Winkler, K., Juergens, H., Goebel, U., COALL Study Groups. (1987). Early Intensification Therapy in High-Risk Childhood Acute Lymphocytic Leukemia: Lack of Benefit from High-Dose Methotrexate. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_80

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  • DOI: https://doi.org/10.1007/978-3-642-71213-5_80

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16556-9

  • Online ISBN: 978-3-642-71213-5

  • eBook Packages: Springer Book Archive

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