Surface Marker Analysis by Monoclonal Antibodies: A Valuable Technique in Childhood Acute Myeloid Leukemia

  • W. D. Ludwig
  • F. Herrmann
  • A. Gatzke
  • M. Budde
  • U. Creutzig
  • J. Ritter
  • G. Schellong
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


A considerable number of monoclonal antibodies (MoAbs) with myeloid activity have been described during the last few years (summarized in [1]). These MoAbs have been applied to the study of normal myeloid differentiation, as well as to the surface marker analysis of acute myeloid leukemia (AML) [2–6]. Although there is a strong tendency for morphological differentiation to correspond to surface antigen differentiation of malignant myeloid cells [2, 3], a recent report has failed to correlate the FAB classification system with immunologic categories of AML [6].


Acute Myeloid Leukemia Acute Leukemia Acute Myeloblastic Leukemia Childhood Acute Myeloid Leukemia Surface Marker Analysis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • W. D. Ludwig
    • 1
  • F. Herrmann
    • 2
  • A. Gatzke
    • 1
  • M. Budde
    • 3
  • U. Creutzig
    • 4
  • J. Ritter
    • 4
  • G. Schellong
    • 4
  1. 1.Departments of Hematology/OncologyKlinikum SteglitzGermany
  2. 2.Departments of Hematology/OncologyUniversity of MainzGermany
  3. 3.Departments of PediatricsUniversity of HannoverGermany
  4. 4.Departments of PediatricsUniversity of MünsterFederal Republic of Germany

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