Intensive Induction and Consolidation Chemotherapy for Adults and Children with Acute Myeloid Leukaemia (AML) Joint AML Trial 1982–1985
Complete remission (CR) can now be obtained in approximately 75% of patients presenting with AML [1–4]. It is not certain, however, whether subsequent intensive therapy (“consolidation”) will prolong remission duration in patients achieving CR . Furthermore, if consolidation therapy is important, the optimum number of courses remains to be established. The role of allogeneic bone marrow transplantation (BMT) in such patients is not clear. Although it seems that relapse rates after BMT are lower than those observed after chemotherapy, overall survival in the former group may not be superior due to increased deaths following transplant-related complications [6, 7].
KeywordsLeukemia Pneumonia Methotrexate Melphalan Stein
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