Pharmacokinetic Study of Cytosine Arabinoside in Patients with Acute Myelogeneous Leukemia

  • P. Preusser
  • H. J. Pielken
  • H.-J. Bauch
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


The aim of the study was to evaluate the pharmacokinetics of cytosine arabinoside (Ara-C) and its extracellular metabolite uracil arabinoside Ara-U in patients with acute myelogeneous leukemia (AML) in correlation to response in therapy. There are few data [4] that indicate that high and long-lasting Ara-U plasma levels increase the incorportion of Ara-C into DNA and decrease the catabolism of Ara-C, and might also play a role in getting a response in therapy. We therefore investigated the pharmacokinetics of Ara-C and Ara-U in plasma of 17 patients with AML.


Acute Myelogeneous Leukemia Kinetic Curf Cytosine Arabinoside Area Under Curve Uracil Arabinoside 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • P. Preusser
    • 1
  • H. J. Pielken
    • 1
  • H.-J. Bauch
    • 2
  1. 1.Departments of Internal MedicineUniversity of Münster ClinicMünsterFederal Republic of Germany
  2. 2.Arteriosclerosis Research InstituteUniversity of MünsterGermany

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