Pharmacokinetic Study of Cytosine Arabinoside in Patients with Acute Myelogeneous Leukemia
The aim of the study was to evaluate the pharmacokinetics of cytosine arabinoside (Ara-C) and its extracellular metabolite uracil arabinoside Ara-U in patients with acute myelogeneous leukemia (AML) in correlation to response in therapy. There are few data  that indicate that high and long-lasting Ara-U plasma levels increase the incorportion of Ara-C into DNA and decrease the catabolism of Ara-C, and might also play a role in getting a response in therapy. We therefore investigated the pharmacokinetics of Ara-C and Ara-U in plasma of 17 patients with AML.
KeywordsHPLC Leukemia Nucleoside Cytosine Uracil
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