Abstract
In a small percentage of acute leukemias the lineage specificity of blasts remains undetermined after morphologic, cytochemical, and immunologic analyses. Some of these cases may coexpress markers of different cell lineages, suggesting their origin from a multipotent precursor cell or an aberrant gene expression [1–3].
Supported by the Deutsche Forschungsgemeinschaft, SFB 112, B 3.
This is a preview of subscription content, log in via an institution to check access.
Preview
Unable to display preview. Download preview PDF.
References
Thiel E, Rodt H, Huhn D, Netzel B, Grosse-Wilde H, Ganeshaguru K, Thierfelder S (1980) Multimarker classification of acute lymhoblastic leukemia: evidence for further T subgroups and evaluation of their clinical significance. Blood 56: 759–772
Smith JL, Curtis JE, Messner HA, Senn JS, Furthmayr H, McCulloch EA (1983) Lineage infidelity in acute leukemia. Blood 61: 1138 1145
Neame PB, Soamboonsrup P, Browman G, Barr RD, Saeed N, Chan B, Pai M, Benger A, Wilson WEC, Walker IR, McBride JA (1985) Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemias. Blood 65: 142–148
Marie JP, Perrot JY, Boucheix C, Zittoun J, Martyre MC, Kayibanda M, Rosenfeld C, Mishal Z, Zittoun R (1982) Determination of ultrastructural peroxidases and immunologic membrane markers in the diagnosis of acute leukemias. Blood 59: 270–276
Youness E, Trujillo JM, Ahearn MJ, McCredie KB, Cork A (1980) Acute unclassified leukemia. A clinicopathologic study with
diagnostic implication of electron microscopy. Am J Hematol 9:79–88
Shkolnik T, Schlossmann SF, Griffin JD (1985) Acute undifferentiated leukemia: induction of partial differentiation by phorbol ester. Leuk Res 9: 11–17
Polliack A, Leizerowitz R, Korkesh A, Gurfel D, Gamliel H, Galili U (1982) Exposure to phorbol diester ( TPA) in vitro as an aid in the classification of blasts in human myelogenous and lymphoid leukemias• in vitro differentiation, growth patterns, and ultrastructural observations. Am J Hematol 13: 199–211
Löffler H (1975) Biochemical properties of leukemic blast cells revealed by cytochemical methods: their relation to prognosis. In: Fliedner TM, Perry S (eds) Prognostic factors in human acute leukemia. Pergamon, Braunschweig, pp 63–173
Greaves MF, Bell R, Amess J, Lister TA (1983) ALL masquerading as AUL. Leuk 7: 735–746
Ganser A, Elstner E, Hoelzer D (1985) Megakaryocytic cells in mixed haemopoietic colonies ( CFU-GEMM) from the peripheral blood of normal individuals. Brit J Haematol 59: 627–633
Roels F, Wisse E, De Brest B, van der Meulen J (1975) Cytochemical discrimination between catalases and peroxidases using diaminobenzidine. Histochemistry 41: 281–312
Paietta E, Bettelheim P, Schwarzmeier JD, Lutz D, Majdic O, Knapp W (1983) Distinct lymphoblastic and myeloblastic populations in TdT-positive acute myeloblastic leukemia: evidence of double fluorescence staining. Leuk Res 7: 301–308
Himori T, Tanaka T, Ohnuma T (1985) Ultrastructural peroxidase cytochemistry of three established human myelogenous leukemia cell lines, HL-60, KG-1 and ML-2. Leuk Res 9: 913–919
Dvorak AM, Monahan RA, Dickersin GR (1981) Diagnostic electron microscopy-I. Hematology: differential diagnosis of acute lymphoblastic and acute myeloblastic leukemia. Use of ultrastructural peroxidase cytochemistry and routine electron microscopic technology. Pathol Annu 16, Part 1: 101–137
Catovsky D, De Salvo Cardullo L, O’Brien M, Morilla R, Costello C, Galton D, GaneshAguru K, Hoffbrand V (1981 b) Cytochemical markers of differentiation in acute leukemia. Cancer Res 41: 4824–4832
Abrahm J, Rovera G (1980) The effect of tumor-promoting phorbol diesters on terminal differentiation of cells in culture. Mol Cell Biochem 31: 165–175
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Heil, G., Ganser, A., Hoelzer, D., Kurrle, E., Heit, W., Heimpel, H. (1987). Induction of Early Myeloperoxidase in Acute Unclassified Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_38
Download citation
DOI: https://doi.org/10.1007/978-3-642-71213-5_38
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16556-9
Online ISBN: 978-3-642-71213-5
eBook Packages: Springer Book Archive