Immunoglobulin and T Cell Receptor Gene Rearrangements in Acute Leukemias

  • A. Raghavachar
  • C. R. Bartram
  • E. Kleihauer
  • B. Kubanek
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


Acute leukemias are commonly classified on the basis of morphologic, cytochemical and immunologic criteria. Immunologic techniques, particularly surface antigen analysis using monoclonal antibodies, have related leukemic cells to normal cell counterparts [1]. In general, lineage fidelity is maintained in leukemic blast cells. However, there are exceptions [2, 3]. Recently, molecular analysis using specific Ig and T cell receptor gene probes has become a valuable addition to morphologic, cytochemical and surface marker studies in determining lineage, clonality, and differentiation of leukemic cell populations [4, 5]. We therefore investigated the diagnostic potential of molecular analyses (a) to develop an understanding of the cellular origin of leukemias which cannot be allocated to one of the defined myeloid or lymphoid lineages by cellular phenotypes, and (b) to reveal the clonal development of phenotypic conversion in acute leukemia.


Acute Leukemia Hairy Cell Leukemia Mixed Lineage Leukemia Phenotypic Conversion Leukemic Blast Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. Raghavachar
    • 1
  • C. R. Bartram
    • 2
  • E. Kleihauer
    • 2
  • B. Kubanek
    • 1
  1. 1.Department of Transfusion MedicineUniversity of UlmUlmFederal Republic of Germany
  2. 2.Department of Transfusion Medicine and Pediatrics IIUniversity of UlmUlmFederal Republic of Germany

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