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Acute Leukemias pp 241–250Cite as

Modification of tRNA and Its Applicability for the Assessment of Prognosis, State of Differentiation, and Clonality in Human Leukemias and Lymphomas

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Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 30))

Abstract

The central agents in protein synthesis are tRNA molecules to which amino acids are attached prior to their polymerisation into polypeptides. Besides its role in protein synthesis, tRNA also plays an important role in the regulation of cell metabolism. These regulatory functions involve alterations of tRNA modifications. The modified nucleosides occur at well-defined positions in specific tRNAs (Fig. 1 a).

This work was supported by Wilhelm Sander Stiftung grant 8.2002.2 and Deutsche Forschungsgemeinschaft grant Ke 98/17.

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Authors and Affiliations

  1. Department of Hematology and Oncology, 1st Clinic of Internal Medicine, Technical University of Munich, Germany

    B. Emmerich, G. Meinhardt, P. A. Maubach & J. Rastetter

  2. Institute of Physiologic Chemistry, University of Erlangen, Germany

    E. Zubrod

Authors
  1. B. Emmerich
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  2. G. Meinhardt
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  3. P. A. Maubach
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  4. E. Zubrod
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  5. J. Rastetter
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  6. W. Kersten
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Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann , D. Urbanitz  & J. Ritter , , ,  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Emmerich, B., Meinhardt, G., Maubach, P.A., Zubrod, E., Rastetter, J., Kersten, W. (1987). Modification of tRNA and Its Applicability for the Assessment of Prognosis, State of Differentiation, and Clonality in Human Leukemias and Lymphomas. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_35

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  • DOI: https://doi.org/10.1007/978-3-642-71213-5_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16556-9

  • Online ISBN: 978-3-642-71213-5

  • eBook Packages: Springer Book Archive

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