Therapy Results in Five ALL-BFM Studies Since 1970: Implications of Risk Factors for Prognosis

  • H. Riehm
  • H.-J. Feickert
  • M. Schrappe
  • G. Henze
  • G. Schellong
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)


Prognosis in childhood acute lymphoblastic leukemia (ALL) after risk-adapted therapy is first of all dependent on the quality of therapy. Conventional risk factors such as WBC, age, sex, organ involvement, and other features certainly have lost their prognostic significance in varying degrees during the evolution of risk-adapted and necessarily intensive therapy. Still, the tumor burden and other ill-defined or unknown factors are responsible for therapy failure. Obviously, the patient group with therapy failure must be the target of future efforts.


Acute Lymphoblastic Leukemia Medium Risk Childhood Acute Lymphoblastic Leukemia Late Responder Complete Continuous Remission 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Riehm H, Gadner H, Henze G, Langermann HJ, Odenwald E (1980) The Berlin childhood 7. acute lymphoblastic leukemia therapy study, 1970–1976. Am J Pediatr Haematol Oncol 2: 299–306Google Scholar
  2. 2.
    Henze G, Langermann HJ, Ritter J, Schellong G, Riehm H (1981) Treatment strategy for different risk groups in childhood acute lympho- 8. blastic leukemia: a report from the BFM study group. In: Neth R, Gallo RC, Graf T, Mannweiler K, Winkler K (eds) Modern trends in human leukemia IV. Springer, Berlin Heidelberg New York (Haematology and blood transfusion, vol 26 )Google Scholar
  3. 3.
    Henze G, Langermann HJ, Fengler R, Brandeis M, Evers KG, Gadner H, Hinderfeld L, Jobke A, Kornhuber B, Lampert F, Lasson U, Ludwig R, Müller-Weihrich S, Neidhardt M, Nessler G, Niethammer D, Rister M, Ritter J, Schaaf A, Schellong G, Stollmann B, Treuner J, Wahlen W, Weinel P, Wehinger H, Riehm H (1982) Therapiestudie BFM 79/81 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen: Intensivierte Reinduktionstherapie für Patientengruppen mit unterschiedlichem Rezidivrisiko. Klin Pädiatr 194: 195–203Google Scholar
  4. 4..
    Riehm H, Gadner H, Henze G, Kornhuber B, Langermann HJ, Müller-Weihrich S, Schellong G (1980) Acute lymphoblastic leukemia: treatment results in three BFM studies (19701981). In: Murphy SB, Gilbert JR (eds) Leukemia research: advances in cell biology and treatment. Elsevier, Amsterdam, pp 251–263Google Scholar
  5. 5.
    Lampert F, Henze G, Langermann HJ, Schellong G, Gadner H, Riehm H (1984) Acute lymphoblastic leukemia: current status of therapy in children. In: Thiel E, Thierfelder S (eds) Leukemia. Springer, Berlin Heidelberg New York, pp 159–181 (Recent results in cancer research vol 93 )Google Scholar
  6. 6.
    Langermann HJ, Henze G, Wulf M, Riehm H (1982) Abschätzung der Tumorzellmasse bei der akuten lymphoblastischen Leukämie im Kindesalter: Prognostische Bedeutung und praktische Anwendung. Klin Pädiatr 194: 209213Google Scholar
  7. 7.
    Henze G, Langermann HJ, Brämswig J, Breu H, Gadner H, Schellong G, Welte K, Riehm H (1981) Ergebnisse der Studie BFM 76/79 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen. Klin Pädiatr 193: 145–154PubMedCrossRefGoogle Scholar
  8. 8.
    Müller Weihrich S, Henze G, Langermann HJ, Odenwald E, Riehm H (1984) Kindliche BZell-Lymphome und Leukämien. Verbesserung der Prognosen durch eine für B-Neoplasien konzipierte Therapie der BFM-Studiengruppe. Onkologie 7: 205–208Google Scholar
  9. 9.
    Riehm H, Feickert HJ, Lampert F (1986) Acute Lymphoblastic Leukemia. In: Voute PA, Barrett A, Bloom HJG, Lemerle J, Neidhardt MK (eds) Cancer in children: clinical management. Springer, Berlin Heidelberg New York Tokyo, pp 101–118Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H. Riehm
    • 1
  • H.-J. Feickert
    • 1
  • M. Schrappe
    • 1
  • G. Henze
    • 2
  • G. Schellong
    • 3
  1. 1.Department of PediatricsHannover Medical SchoolHannoverGermany
  2. 2.Department of PediatricsBerlin Free UniversityGermany
  3. 3.Department of PediatricsMünster UniversityFederal Republic of Germany

Personalised recommendations