Abstract
Treatment of acute lymphoblastic leukemia (ALL) in children with effective regimens including induction with vincristine, cytoxan, asparaginase, and prednisone followed by prolonged maintenance with various drug combinations results in complete remission (CR) rates of approximately 90%, with more than 50% of the patients being possibly cured [1]. Use of similar regimens in patients over 15 has, however, been far less successful [2]. During the last decade, considerable improvement has been achieved in the treatment of adult ALL using more intensive regimens, and several protocols including more aggressive induction with anthracyclines followed by intensive consolidation and multidrug maintenance over several years have yielded therapeutic results similar to those obtained in children [3–6] and possibly similar to those achieved by allogeneic bone marrow transplantation [7] with approximately 50% long-term survivors. These regimens, however, are very toxic and may not be suitable for all patients.
The French Group for Treatment of Adult Acute Lymphoblastic (FGTAALL).
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© 1987 Springer-Verlag Berlin Heidelberg
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Fière, D. et al. (1987). Treatment of Adult Acute Lymphoblastic Leukemia. Preliminary Results of a Trial from the French Group. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_19
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DOI: https://doi.org/10.1007/978-3-642-71213-5_19
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