Abstract
Over the past 10 years, leukemias and lymphomas have been analyzed extensively with antibodies and for enzyme activity [1, 2]. More recently, the introduction of monoclonal antibodies (MoAbs) has improved dramatically the precision, practicability, and standardization of immunophenotyping. Meanwhile, immunologic analysis of leukemia cells has become routine clinical practice, and evidence that cell typing with antibodies contributes to final diagnosis, differential diagnosis, and classification of leukemias is compelling [3].
Supported by the Bundesministerium für Forschung und Technologie (BMFT) and by Deutsche Krebshilfe.
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References
Foon KA, Schroff RW, Gale RP (1982) Sur¬face markers on leukemia and lymphoma cells: secent advances. Blood 60: 1 13.
Thiel E (1985) Cell surface markers in leu¬kemia: biological and clinical correlations. CRC Crit Rev Oncol/Hematol 2: 209–259
Chan LC, Pegram SM, Greaves MF (1985) Contribution of immunophenotype to the classification and differential diagnosis of acute leukemia. Lancet I: 475–479 14.
Greaves MFI, Janossy G, Peto J, Kay H (1981) Immunologically defined subclasses of acute lymphoblastic leukemia in children: their relationship to presentation features and prognosis. Br J Haematol 48: 179–198
Kersey J, Goldman A, Abramson C, Nesbit 15. M, Perry G, Gajl-Peczalska K, LeBien T (1982) Clinical usefulness of monoclonal anti¬body phenotyping in childhood acute lym¬phoblastic leukemia. Lancet II: 1419–1423
Thiel E, Rodt H, Huhn D, Netzel B, Grosse-Wilde H, Ganeshaguru K, Thierfelder S (1980) Multimarker classification of acute lymphoblastic leukemia: evidence for further T subgroups and evaluation of their clinical significance. Blood 56: 759–772
Thiel E, Kummer U, Rodt H, Stünkel K, Munker R, Knapp W, Thierfelder S (1982) Comparison of currently available monoclo¬nal antibodies with conventional markers for phenotyping of one hundred acute leukemias. Blut 44: 95
IUIS-WHO nomenclature subcommittee on human leukocyte differentiation antigens(1984). Bull WHO:809–811
Moir DJ, Ghosh AK, Abdulaziz Z, Knight PM, Mason DY (1983) Immunoenzymatic staining of haematological samples with monoclonal antibodies. Br J Haematol 55: 395–410
Pezzuto A, Dörken B, Feller A, Moldenhauer G, Schwarz R, Wernet P, Thiel E, Hunstein W (1986) HD37 monoclonal antibody: A use¬ful reagent for further characterization of “non-T/non-B” lymphoid malignancies. In: Reinherz EL, Haynes BF,Nadler LM,Ben-stin JD(eds)Leukocyte typing,vol 2.Springer,Berlin Heidelberg New York Tokyo,pp 391–402
Korsmeyer SJ, Arnold A, Bakkshi A, Ravetch JV, Siebenlist U, Hieter PA, Sharrow SO, LeBien TW, Kersey JH, Poplack DG, Leder P (1983) Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J clin Invest 7: 301–313
Mirro J, Zipf TF, Pui C-H, Kitchingman G, Williams D, Melvin S, Murphy SB, Stass S (1985) Acute mixed lineage leukemia: clinico-pathologic correlations and prognostic significance. Blood 66: 1115–1123
Kita K, Nasu K, Kamesaki H, Doi S, Tezuka H, Tatsumi E, Fukuhara S, Nishikori M, Uchino H, Shirakawa S (1985) Phenotypic analysis of acute lymphoblastic leukemia ( ALL) cells which are classified as non-T non-B and negative for common ALL antigen. Blood 66: 47–52
Sobol RE, Royston I, LeBien TW, Minowada J, Anderson K, Davey FR, Cuttner J, Schiffer, Ellison RR, Bloomfield CD (1985) Adult acute lymphoblastic leukemia phentotypes defined by monoclonal antibodies. Blood 65: 730–735
Maire JP, Perrot JY, Boucheix C, Zittoun J, Martyre MC, Kayibanda M, Rosenfeld C, Mishal Z, Zittoun R (1982) Determination of ultrastructural peroxidases and immunologic membrane markers in the diagnosis of acute leukemias. Blood 59: 270–276
Gregg SL, Gail-Peczalska KJ, LeBien TW, Bloomfield CD, Brunning R, Sagawa K (1984) Monoclonal antibody MCS-2 as the marker of phorbol diester-induced myeloid differentiation in acute undifferentiated leukemia. Cancer Res 44: 2724–2730
Shkolnik T, Schlossman S, Griffin JD (1985) Acute undifferentiated leukemia: Induction of partial differentiation by phorbol ester. Leuk Res 9: 11–17
Neame PB, Soamboonsrup P, Browman G, Barr RD, Saeed N, Chan B, Pao M, Benger A, Wilson WE, Walker IR, McBride JA (1985) Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemia. Blood 65: 142–148
Gutensohn W, Thiel E (1985) Ecto-5’-nucleotidase as marker for differential diagnosis in acute undifferentiated leukemia in adults. Blut 51 (Astract): 164
Hoelzer D, Thiel E, Löffler H, Bodenstein H, Plaumann L, Büchner T, Urbanitz D, Koch P, Heimpel H, Engelhardt R, Müller U, Wendt F-C, Sodomann H, Rühl H, Herrmann F, Kaboth W, Dietzfelbinger H,Pralle H, Lunscken Ch, Hellriegel K-P, Spors S, Nowrousian RM, Fischer J, Fülle H, Mi-trou PS, Pfreundschuh M, Görg Ch, Emmerich B, Queisser W, Meyer P, Labedzki L, Essers U, König H, Mainzer K, Herrmann R, Messerer D, Zwingers T (1984) Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. Blood 64: 38–47
Crist W, Pullen J, Boyett J, Falletta J, van Eys J, Borowitz M, Jackson J, Dowell B, Frankel L, Quddus F, Ragab A, Vietti T (1986) Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants:a pediatric oncology group study. Blood 67: 135–140
Bloomfield CD, Goldman AI, Alimena G, Berger R, Borgström GH, Brandt L, Catovsky D, de la Chapelle A, Dewald GW, Garson OM, Garwicz S, Golomb HM, Hossfeld DK, Lawler SD, Mitelman F, Nilsson P, Pierre RV, Philip P, Prigogina E, Rowley JD, Sakurai M, Sandberg AA, Secker Walker LM, Tricot G, Van Den Berghe H, Van Orshoven A, Vuopio P, Whang-Peng J (1986) Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia. Blood 67: 412–420
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Thiel, E., Hoelzer, D., Dörken, B., Löffler, H., Messerer, C., Huhn, D. (1987). Clinical Relevance of Blast Cell Phenotype as Determined with Monoclonal Antibodies in Acute Lymphoblastic Leukemia of Adults . In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_16
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DOI: https://doi.org/10.1007/978-3-642-71213-5_16
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