Abstract
With the isolation of specific antibodies and cDNA clones it has recently become possible to study the molecular nature of the T-cell receptor that had for an unusually long time resisted characterization (for a review see, Möller 1984). It has by now been firmly established that the T-cell receptor genes are members of the so-called immunoglobulin superfamily which includes the immunoglobulin, T-cell receptor, MHC class I and class II, T4, T8, Thy-1, Ox-2 and poly (preceptor genes (Hood et al. 1985; Williams 1985). The T-cell receptor genes use the same strategies as the immunoglobulin genes to generate diversity — namely, splitting of the coding information into a number of small gene segments and diversification of these segments by various somatic mechanisms (reviewed in Steinmetz 1986). In the following, we will briefly review the organization and rearrangement of the T-cell receptor gene segments and compare somatic diversification mechanisms of immunoglobulin and T-cell receptor genes.
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© 1986 Springer-Verlag Berlin Heidelberg
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Steinmetz, M., Dembić, Z. (1986). Organization, Rearrangement, and Diversification of Mouse T-Cell Receptor Genes. In: Fleischer, B., Reimann, J., Wagner, H. (eds) Specificity and Function of Clonally Developing T Cells. Current Topics in Microbiology and Immunology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71152-7_6
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DOI: https://doi.org/10.1007/978-3-642-71152-7_6
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