Functional Analysis of a Self-I-A Reactive T-Cell Clone Which Preferentially Stimulates Activated B Cells

  • T. Saito
  • K. Rajewsky
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 126)


Autoreactive T cells have been isolated in the form of continuously growing lines (Zauderer et al. 1984; Clayberger et al. 1984; Kimoto et al. 1984; Finnegan et al. 1984) or hybridomas (Glimcher and Shevach 1982; Rock and Benacerraf 1983, Endres et al. 1983; Nagase et al. 1984). Such T cells may participate in syngeneic mixed lymphocyte reaction (reviewed by Battisto and Ponzio 1981). However, it is not clear whether they play a regulatory role under physiological conditions (Hausman and Stobo 1979; Smith and Knowlton 1979; Lattime et al. 1981; Goto and Zvaifler 1983).


Keyhole Limpet Hemocyanin Helper Function Autologous Mixed Lymphocyte Reaction Syngeneic Spleen Cell Splenic Adherent Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • T. Saito
    • 1
  • K. Rajewsky
    • 1
  1. 1.Institute for GeneticsUniversity of CologneCologneGermany

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