Functional Analysis of a Self-I-A Reactive T-Cell Clone Which Preferentially Stimulates Activated B Cells
Autoreactive T cells have been isolated in the form of continuously growing lines (Zauderer et al. 1984; Clayberger et al. 1984; Kimoto et al. 1984; Finnegan et al. 1984) or hybridomas (Glimcher and Shevach 1982; Rock and Benacerraf 1983, Endres et al. 1983; Nagase et al. 1984). Such T cells may participate in syngeneic mixed lymphocyte reaction (reviewed by Battisto and Ponzio 1981). However, it is not clear whether they play a regulatory role under physiological conditions (Hausman and Stobo 1979; Smith and Knowlton 1979; Lattime et al. 1981; Goto and Zvaifler 1983).
KeywordsKeyhole Limpet Hemocyanin Helper Function Autologous Mixed Lymphocyte Reaction Syngeneic Spleen Cell Splenic Adherent Cell
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