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T-Cell Reactivity to Polymorphic MHC Determinants I. MHC-Guided T-Cell Reactivity

  • J. Reimann
  • K. Heeg
  • D. Kabelitz
  • H. Wagner
  • R. G. Miller
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 126)

Abstract

The function of major histocompatibility complex (MHC) molecules remains elusive. Our detailed knowledge of their structural (genetic and biochemical) features contrasts sharply with our essentially speculative ideas concerning their function(s), which furthermore seem at present to be locked into sets of mutually exclusive hypotheses.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Molecule Allelic Major Histocompatibility Complex Major Histocompatibility Complex Haplotype Clonal Selection Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alt B, Baltimore D (1982) Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D J ( H) fusions. Proc Natl Acad Sci USA 78: 5812Google Scholar
  2. Andersson J, Coutinho A, Melchers F (1977) Frequencies of mitogen-reactive B cells in the mouse. II. Frequencies of B cells producing antibodies which lyse sheep or horse erythrocytes and tri- nitrophenylated or nitroiodophenylated sheep erythrocytes. J Exp Med 145: 1520PubMedCrossRefGoogle Scholar
  3. Augustin AA, Sim GK (1984) T-cell receptors generated via mutations are specific for various major histocompatibility antigens. Cell 39: 5PubMedCrossRefGoogle Scholar
  4. Baltimore D (1981) Somatic mutation gains its place among the generators of diversity. Cell 26: 295PubMedCrossRefGoogle Scholar
  5. Bartlett PF, Edidin M (1977) Effect of the H-2 gene complex on rates of fibroblast intercellular adhesion. J Cell Biol 77: 377CrossRefGoogle Scholar
  6. Bodmer WF (1972) Evolutionary significance of the HLA system. Nature 237: 139PubMedCrossRefGoogle Scholar
  7. Burnet FM (1959) The clonal selection theory of acquired immunity. Vanderbilt, Nashville, TNGoogle Scholar
  8. Cohn M (1983) The T-cell receptor mediating restrictive recognition of antigen. Cell 33: 657PubMedCrossRefGoogle Scholar
  9. Coutinho A (1980) The self-non-self discrimination and the nature and acquisition of the antibody repertoire. Ann Immunol (Inst Pasteur) 131D: 235Google Scholar
  10. Cunningham AJ (1974) The generation of antibody diversity: its dependence on antigenic stimulation. Contemp Top Immunol 3: 1Google Scholar
  11. Cunningham AJ, Fordham SA (1974) Antibody cell daughters can produce antibody of different specificities. Nature 250: 669PubMedCrossRefGoogle Scholar
  12. Cunningham AJ, Pilarski LM (1974a) The generation of antibody diversity. I. Kinetics of production of different antibody specificities during the course of an immune response. Eur J Immunol 4: 319PubMedCrossRefGoogle Scholar
  13. Cunningham AJ, Pilarski LM (1974b) The generation of antibody diversity. II. Plaque morphology as a simple marker for antibody specificity at the single cell level. Eur J Immunol 4: 757PubMedCrossRefGoogle Scholar
  14. Curtis ASG (1979) Histocompatibility systems, recognition and cell positioning. Dev Comp Immunol 3: 379PubMedCrossRefGoogle Scholar
  15. Dausset J, Contu L (1980) Is the MHC a general self-recognition system playing a major unifying role in organisms? Hum Immunol 1: 5PubMedCrossRefGoogle Scholar
  16. Diamond B, Scharff MD (1984) Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci USA 81: 5841PubMedCrossRefGoogle Scholar
  17. Doherty PC, Biddison WE, Bennink JR, Knowles BB (1978) Cytotoxic T cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype. J Exp Med 148: 534PubMedCrossRefGoogle Scholar
  18. Dos Reis GA, Shevach EM (1983) Antigen-presenting cells from nonresponder strain 2 guinea pigs are fully competent to present bovine insulin B chain to responder strain 2 T cells. Evidence against a determinant selection model and in favor of a clonal deletion model of immune response gene function. J Exp Med 157: 1287PubMedCrossRefGoogle Scholar
  19. Edidin M (1983) MHC antigens and non-immune functions. Immunol Today 4: 269CrossRefGoogle Scholar
  20. Eichmann K, Fey K, Kuppers K, Melchers I, Simon MM, Weltzien HU (1983) Network regulation among T-cells: conclusions from limiting dilution experiments. Springer Semin Immunopathol 6: 7PubMedCrossRefGoogle Scholar
  21. Forman J (1975) On the role of the H-2 histocompatibility complex in determining the specificity of cytotoxic effector cells sensitized against syngeneic trinitrophenyl-modified targets. J Exp Med 142: 403PubMedCrossRefGoogle Scholar
  22. Fujiwara H, Tsuchida T, Levy RB, Shearer GM (1982) H-2Kk can influence whether cytotoxic T lymphocytes recognize trinitrophenyl in assocation with H-2Dk unique or H-2Kk and H-2Dk shared self determinants. J Immunol 129: 1189PubMedGoogle Scholar
  23. Gomard E, Duprez V, Reme T, Colombani MJ, Levy JP (1977) Exclusive involvement of H-2Db or H-2Kd product in the interaction between T-killer lymphocytes and syngeneic H-2b or H-2d viral lymphomas. J Exp Med 146: 909PubMedCrossRefGoogle Scholar
  24. Goverman J, Minard K, Shastri N, Hunkapiller T, Hansburg D, Sercarz E, Hood L (1985) Rearranged T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V and MHC restriction. Cell 40: 859PubMedCrossRefGoogle Scholar
  25. Guimezanes A, Albert F, Schmitt-Verhulst AM (1982) I region-restricted T cell line stimulated with hapten-treated syngeneic cells: selection of clones with reactivity for both allogeneic la determinants and self-I-A plus hapten. Eur J Immunol 12: 195PubMedCrossRefGoogle Scholar
  26. Haman U, Eichmann K, Krammer PH (1983) Frequencies and regulation of trinitrophenyl-specific cytotoxicT-precursor cells: immunization results in release from suppression. J Immunol 130: 7Google Scholar
  27. Heeg K, Zielinski I, Kabelitz D, Wagner H, Reimann J (1985) Anti-MHC reactive T-cells. I I. Clonal specificity of mitogen activated cytotoxic T-lymphoblasts. ( Submitted )Google Scholar
  28. Ishikawa H, Dutton RW (1979) Primary in vitro cytotoxic response of F1T lymphocytes against parental antigens. J Immunol 122: 529PubMedGoogle Scholar
  29. Johnson LL, Bailey DW, Mobraaten LE (1981) Antigenic competition between minor non-H-2 histocompatibility antigens. Immunogenetics 13: 451PubMedCrossRefGoogle Scholar
  30. Kim S, Davis M, Sinn E, Patten P, Hood L (1981) Antibody diversity: somatic hypermutation of rearranged Vh genes. Cell 27: 573PubMedCrossRefGoogle Scholar
  31. Kimura AK, Wigzell H (1983) Development and function of cytotoxic T lymphocytes (CTL). I. In vivo maturation of CTL precursors in the absence of detectable proliferation results as a normal consequence of alloimmunization. J Immunol 130: 2058Google Scholar
  32. Klein J, Figueroa F (1981) Polymorphism of the mouse H-2 loci. Immunol Rev 60: 23PubMedCrossRefGoogle Scholar
  33. Lengerova A, Zeleny V, Haskovec C, Hilgert I (1977) Search for the physiological function of H-2 gene products. Eur J Immunol 7: 62PubMedCrossRefGoogle Scholar
  34. MacDonald HR, Glasebrook AL, Bron C, Kelsoe A, Cerottini JC (1982) Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors. Immunol Rev 68: 89PubMedCrossRefGoogle Scholar
  35. Matzinger P (1981) A one-receptor view of T-cell behavior. Nature 292: 497PubMedCrossRefGoogle Scholar
  36. Matzinger P, Bevan MJ (1977) Hypothesis. Why do so many lymphocytes respond to major histocompatibility antigens? Cell Immunol 29: 1PubMedCrossRefGoogle Scholar
  37. Matzinger P, Zamoyska R, Waldmann H (1984) Self-tolerance is H-2 restricted. Nature 308: 738PubMedCrossRefGoogle Scholar
  38. McKean D, Huppi K, Bell M, Staudt L, Gerhardt W, Weigert M (1984) Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc Natl Acad Sci USA 81: 3180PubMedCrossRefGoogle Scholar
  39. Mitchison NA, Petterson S (1983) Does clonal selection occur among T-cells? Ann Immun (Inst Pasteur) 134D: 37CrossRefGoogle Scholar
  40. Nakamura I, Cudkowicz G (1982) Fine specificity of auto- and allo-reactive cytotoxic T lymphocytes: heteroclitic cross-reactions between mutant and original H-2 antigens. Curr Top Microbiol 99: 51Google Scholar
  41. Nakano K, Nakamura I, Cudkowicz G (1981) Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2. Nature 289: 559PubMedCrossRefGoogle Scholar
  42. Potter TA, Palladino MA, Wilson DB, Rajan TV (1983) Epitopes on H-2Dd somatic cell mutantsrecognized by cytotoxic T cells. J Exp Med 158: 1061PubMedCrossRefGoogle Scholar
  43. Rammensee HG, Bevan MJ (1984) Evidence from in vitro studies that tolerance to self antigens is MHC restricted. Nature 308: 741PubMedCrossRefGoogle Scholar
  44. Reimann J, Miller RG (1983a) Differentiation from precursors in athymic nude mouse bone marrow of unusual spontaneously cytolytic cells showing anti-self H-2 specificity and bearing T cell markers. J Exp Med 158: 1672PubMedCrossRefGoogle Scholar
  45. Reimann J, Miller RG (1983b) Generation of autoreactive cytotoxic T lymphocytes under limiting dilution conditions. J Immunol 131: 2128PubMedGoogle Scholar
  46. Reimann J, Miller RG (1983c) Polymorphism and MHC gene function. Dev Comp Immunol 7: 403PubMedCrossRefGoogle Scholar
  47. Reimann J, Miller RG (1985) Rapid changes in specificity within single clones of cytolytic effector cells. Cell 40: 571PubMedCrossRefGoogle Scholar
  48. Reimann J, Heeg K, Miller RG, Wagner H (1985a) Allorective T-cells. I. Alloreactive and allore-stricted cytotoxic T-cells. Eur J Immunol 15: 387PubMedCrossRefGoogle Scholar
  49. Reimann J, Kabelitz D, Heeg K, Wagner H (1985b) Allorestricted cytotoxic T-cells. Large numbers of allo-H-2Kb-restricted anti-hapten and anti-viral cytotoxic T-cell populations clonally develop in vitro from murine splenic precursor T-cells. J Exp Med 162: 592PubMedCrossRefGoogle Scholar
  50. Sablitzky F, Rajewsky K (1984) Molecular basis of an isogenic anti-idiotypic response. EMBO J 3: 3005PubMedGoogle Scholar
  51. Scofield VL, Schlumpberger JM, West LA, Weissman I (1982) Protochordate allorecognition is controlled by a MHC-like gene system. Nature 295: 499PubMedCrossRefGoogle Scholar
  52. Shearer GM, Rehn TG, Garbarino CA (1975) Cell-mediated lympholysis of trinitrophenyl-modifiedautologous lymphocytes. J Exp Med 141: 1348PubMedCrossRefGoogle Scholar
  53. Sherman LA (1980) Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire. J Exp Med 151: 1386PubMedCrossRefGoogle Scholar
  54. Sherman LA (1982a) Genetic and regulatory contributions of the major histocompatibility complex to the developing cytolytic T lymphocyte repertoire. J Immunol 128: 1849PubMedGoogle Scholar
  55. Sherman LA (1982b) Influence of the major histocompatibility complex on the repertoire of allospecific cytolytic T lymphocytes. J Exp Med 154: 987Google Scholar
  56. Sherman L (1985) The cytolytic T lymphocyte receptor repertoire of H-2 disparate cells obtained from double parental chimeras. J Immunol 1: 63Google Scholar
  57. Sherman LA, Vitiello A, Klinman NR (1983) T-cell and B-cell responses to viral antigens at the clonal level Ann Rev Immunol 1: 63Google Scholar
  58. Simonsen M, Olsson L (1983) Possible roles of compound membrane receptors in immune system. Ann Immun (Inst Pasteur) 134D: 85CrossRefGoogle Scholar
  59. Simpson E (1982) The role of H-Y as a minor transplantation antigen. Immunol Today 3: 97CrossRefGoogle Scholar
  60. Streilin JW (1979) Neonatal tolerance: towards an immunological definition of self. Immunol Rev 46: 125CrossRefGoogle Scholar
  61. Streilin JW (1981) Hamster immune responsiveness and experimental models of infectious and oncologic diseases. Fed Proc 40: 2343Google Scholar
  62. Streilin JW, Duncan WR (1983) On the anomalous nature of the major histocompatibility complex in Syrian hamsters, Hm-1. Transplant Proc 15: 1540Google Scholar
  63. Swain SL (1980) Association of Ly phenotypes, T cell function and MHC recognition. Fed Proc 39: 3110PubMedGoogle Scholar
  64. Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302: 575PubMedCrossRefGoogle Scholar
  65. Vidovic D, Klein J, Nagy ZA (1984) The role of T cell subsets in the generation of secondary cytolytic responses in vitro against class I and class II major histocompatibility complex antigens. J Immunol 132: 1113PubMedGoogle Scholar
  66. von Boehmer H, Haas W, Jerne NK (1978) Major histocompatibility complex-linked immune re-sponsiveness is acquired by lymphocytes of low responder mice differentiating in thymus of high responder mice. Proc Natl Acad Sci USA 75: 2439CrossRefGoogle Scholar
  67. Wettstein PJ, Bailey DW (1982) Immunodominance in the immune response to “multiple” histocompatibility antigens. Immunogenetics 16: 47PubMedCrossRefGoogle Scholar
  68. Wraith DC (1984) Derestricted antiinfluenza cytotoxic T-cell clone loses one of its two alloreactivities. Immunogenetics 20: 131PubMedCrossRefGoogle Scholar
  69. Zinkernagel RM, Althage A, Cooper S, Kreeb G, Klein PA, Sefton B, Flaherty L, Stimpfling J, Shreffler D, Klein J (1978) Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominants of responsiveness. J Exp Med 148: 592PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. Reimann
    • 1
  • K. Heeg
    • 1
  • D. Kabelitz
    • 1
  • H. Wagner
    • 1
  • R. G. Miller
    • 2
  1. 1.Institute of Medical Microbiology and ImmunologyUniversity of UlmUlmGermany
  2. 2.Ontario Cancer InstituteTorontoCanada

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