Abstract
The function of major histocompatibility complex (MHC) molecules remains elusive. Our detailed knowledge of their structural (genetic and biochemical) features contrasts sharply with our essentially speculative ideas concerning their function(s), which furthermore seem at present to be locked into sets of mutually exclusive hypotheses.
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References
Alt B, Baltimore D (1982) Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D J ( H) fusions. Proc Natl Acad Sci USA 78: 5812
Andersson J, Coutinho A, Melchers F (1977) Frequencies of mitogen-reactive B cells in the mouse. II. Frequencies of B cells producing antibodies which lyse sheep or horse erythrocytes and tri- nitrophenylated or nitroiodophenylated sheep erythrocytes. J Exp Med 145: 1520
Augustin AA, Sim GK (1984) T-cell receptors generated via mutations are specific for various major histocompatibility antigens. Cell 39: 5
Baltimore D (1981) Somatic mutation gains its place among the generators of diversity. Cell 26: 295
Bartlett PF, Edidin M (1977) Effect of the H-2 gene complex on rates of fibroblast intercellular adhesion. J Cell Biol 77: 377
Bodmer WF (1972) Evolutionary significance of the HLA system. Nature 237: 139
Burnet FM (1959) The clonal selection theory of acquired immunity. Vanderbilt, Nashville, TN
Cohn M (1983) The T-cell receptor mediating restrictive recognition of antigen. Cell 33: 657
Coutinho A (1980) The self-non-self discrimination and the nature and acquisition of the antibody repertoire. Ann Immunol (Inst Pasteur) 131D: 235
Cunningham AJ (1974) The generation of antibody diversity: its dependence on antigenic stimulation. Contemp Top Immunol 3: 1
Cunningham AJ, Fordham SA (1974) Antibody cell daughters can produce antibody of different specificities. Nature 250: 669
Cunningham AJ, Pilarski LM (1974a) The generation of antibody diversity. I. Kinetics of production of different antibody specificities during the course of an immune response. Eur J Immunol 4: 319
Cunningham AJ, Pilarski LM (1974b) The generation of antibody diversity. II. Plaque morphology as a simple marker for antibody specificity at the single cell level. Eur J Immunol 4: 757
Curtis ASG (1979) Histocompatibility systems, recognition and cell positioning. Dev Comp Immunol 3: 379
Dausset J, Contu L (1980) Is the MHC a general self-recognition system playing a major unifying role in organisms? Hum Immunol 1: 5
Diamond B, Scharff MD (1984) Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci USA 81: 5841
Doherty PC, Biddison WE, Bennink JR, Knowles BB (1978) Cytotoxic T cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype. J Exp Med 148: 534
Dos Reis GA, Shevach EM (1983) Antigen-presenting cells from nonresponder strain 2 guinea pigs are fully competent to present bovine insulin B chain to responder strain 2 T cells. Evidence against a determinant selection model and in favor of a clonal deletion model of immune response gene function. J Exp Med 157: 1287
Edidin M (1983) MHC antigens and non-immune functions. Immunol Today 4: 269
Eichmann K, Fey K, Kuppers K, Melchers I, Simon MM, Weltzien HU (1983) Network regulation among T-cells: conclusions from limiting dilution experiments. Springer Semin Immunopathol 6: 7
Forman J (1975) On the role of the H-2 histocompatibility complex in determining the specificity of cytotoxic effector cells sensitized against syngeneic trinitrophenyl-modified targets. J Exp Med 142: 403
Fujiwara H, Tsuchida T, Levy RB, Shearer GM (1982) H-2Kk can influence whether cytotoxic T lymphocytes recognize trinitrophenyl in assocation with H-2Dk unique or H-2Kk and H-2Dk shared self determinants. J Immunol 129: 1189
Gomard E, Duprez V, Reme T, Colombani MJ, Levy JP (1977) Exclusive involvement of H-2Db or H-2Kd product in the interaction between T-killer lymphocytes and syngeneic H-2b or H-2d viral lymphomas. J Exp Med 146: 909
Goverman J, Minard K, Shastri N, Hunkapiller T, Hansburg D, Sercarz E, Hood L (1985) Rearranged T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V and MHC restriction. Cell 40: 859
Guimezanes A, Albert F, Schmitt-Verhulst AM (1982) I region-restricted T cell line stimulated with hapten-treated syngeneic cells: selection of clones with reactivity for both allogeneic la determinants and self-I-A plus hapten. Eur J Immunol 12: 195
Haman U, Eichmann K, Krammer PH (1983) Frequencies and regulation of trinitrophenyl-specific cytotoxicT-precursor cells: immunization results in release from suppression. J Immunol 130: 7
Heeg K, Zielinski I, Kabelitz D, Wagner H, Reimann J (1985) Anti-MHC reactive T-cells. I I. Clonal specificity of mitogen activated cytotoxic T-lymphoblasts. ( Submitted )
Ishikawa H, Dutton RW (1979) Primary in vitro cytotoxic response of F1T lymphocytes against parental antigens. J Immunol 122: 529
Johnson LL, Bailey DW, Mobraaten LE (1981) Antigenic competition between minor non-H-2 histocompatibility antigens. Immunogenetics 13: 451
Kim S, Davis M, Sinn E, Patten P, Hood L (1981) Antibody diversity: somatic hypermutation of rearranged Vh genes. Cell 27: 573
Kimura AK, Wigzell H (1983) Development and function of cytotoxic T lymphocytes (CTL). I. In vivo maturation of CTL precursors in the absence of detectable proliferation results as a normal consequence of alloimmunization. J Immunol 130: 2058
Klein J, Figueroa F (1981) Polymorphism of the mouse H-2 loci. Immunol Rev 60: 23
Lengerova A, Zeleny V, Haskovec C, Hilgert I (1977) Search for the physiological function of H-2 gene products. Eur J Immunol 7: 62
MacDonald HR, Glasebrook AL, Bron C, Kelsoe A, Cerottini JC (1982) Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors. Immunol Rev 68: 89
Matzinger P (1981) A one-receptor view of T-cell behavior. Nature 292: 497
Matzinger P, Bevan MJ (1977) Hypothesis. Why do so many lymphocytes respond to major histocompatibility antigens? Cell Immunol 29: 1
Matzinger P, Zamoyska R, Waldmann H (1984) Self-tolerance is H-2 restricted. Nature 308: 738
McKean D, Huppi K, Bell M, Staudt L, Gerhardt W, Weigert M (1984) Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc Natl Acad Sci USA 81: 3180
Mitchison NA, Petterson S (1983) Does clonal selection occur among T-cells? Ann Immun (Inst Pasteur) 134D: 37
Nakamura I, Cudkowicz G (1982) Fine specificity of auto- and allo-reactive cytotoxic T lymphocytes: heteroclitic cross-reactions between mutant and original H-2 antigens. Curr Top Microbiol 99: 51
Nakano K, Nakamura I, Cudkowicz G (1981) Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2. Nature 289: 559
Potter TA, Palladino MA, Wilson DB, Rajan TV (1983) Epitopes on H-2Dd somatic cell mutantsrecognized by cytotoxic T cells. J Exp Med 158: 1061
Rammensee HG, Bevan MJ (1984) Evidence from in vitro studies that tolerance to self antigens is MHC restricted. Nature 308: 741
Reimann J, Miller RG (1983a) Differentiation from precursors in athymic nude mouse bone marrow of unusual spontaneously cytolytic cells showing anti-self H-2 specificity and bearing T cell markers. J Exp Med 158: 1672
Reimann J, Miller RG (1983b) Generation of autoreactive cytotoxic T lymphocytes under limiting dilution conditions. J Immunol 131: 2128
Reimann J, Miller RG (1983c) Polymorphism and MHC gene function. Dev Comp Immunol 7: 403
Reimann J, Miller RG (1985) Rapid changes in specificity within single clones of cytolytic effector cells. Cell 40: 571
Reimann J, Heeg K, Miller RG, Wagner H (1985a) Allorective T-cells. I. Alloreactive and allore-stricted cytotoxic T-cells. Eur J Immunol 15: 387
Reimann J, Kabelitz D, Heeg K, Wagner H (1985b) Allorestricted cytotoxic T-cells. Large numbers of allo-H-2Kb-restricted anti-hapten and anti-viral cytotoxic T-cell populations clonally develop in vitro from murine splenic precursor T-cells. J Exp Med 162: 592
Sablitzky F, Rajewsky K (1984) Molecular basis of an isogenic anti-idiotypic response. EMBO J 3: 3005
Scofield VL, Schlumpberger JM, West LA, Weissman I (1982) Protochordate allorecognition is controlled by a MHC-like gene system. Nature 295: 499
Shearer GM, Rehn TG, Garbarino CA (1975) Cell-mediated lympholysis of trinitrophenyl-modifiedautologous lymphocytes. J Exp Med 141: 1348
Sherman LA (1980) Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire. J Exp Med 151: 1386
Sherman LA (1982a) Genetic and regulatory contributions of the major histocompatibility complex to the developing cytolytic T lymphocyte repertoire. J Immunol 128: 1849
Sherman LA (1982b) Influence of the major histocompatibility complex on the repertoire of allospecific cytolytic T lymphocytes. J Exp Med 154: 987
Sherman L (1985) The cytolytic T lymphocyte receptor repertoire of H-2 disparate cells obtained from double parental chimeras. J Immunol 1: 63
Sherman LA, Vitiello A, Klinman NR (1983) T-cell and B-cell responses to viral antigens at the clonal level Ann Rev Immunol 1: 63
Simonsen M, Olsson L (1983) Possible roles of compound membrane receptors in immune system. Ann Immun (Inst Pasteur) 134D: 85
Simpson E (1982) The role of H-Y as a minor transplantation antigen. Immunol Today 3: 97
Streilin JW (1979) Neonatal tolerance: towards an immunological definition of self. Immunol Rev 46: 125
Streilin JW (1981) Hamster immune responsiveness and experimental models of infectious and oncologic diseases. Fed Proc 40: 2343
Streilin JW, Duncan WR (1983) On the anomalous nature of the major histocompatibility complex in Syrian hamsters, Hm-1. Transplant Proc 15: 1540
Swain SL (1980) Association of Ly phenotypes, T cell function and MHC recognition. Fed Proc 39: 3110
Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302: 575
Vidovic D, Klein J, Nagy ZA (1984) The role of T cell subsets in the generation of secondary cytolytic responses in vitro against class I and class II major histocompatibility complex antigens. J Immunol 132: 1113
von Boehmer H, Haas W, Jerne NK (1978) Major histocompatibility complex-linked immune re-sponsiveness is acquired by lymphocytes of low responder mice differentiating in thymus of high responder mice. Proc Natl Acad Sci USA 75: 2439
Wettstein PJ, Bailey DW (1982) Immunodominance in the immune response to “multiple” histocompatibility antigens. Immunogenetics 16: 47
Wraith DC (1984) Derestricted antiinfluenza cytotoxic T-cell clone loses one of its two alloreactivities. Immunogenetics 20: 131
Zinkernagel RM, Althage A, Cooper S, Kreeb G, Klein PA, Sefton B, Flaherty L, Stimpfling J, Shreffler D, Klein J (1978) Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominants of responsiveness. J Exp Med 148: 592
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Reimann, J., Heeg, K., Kabelitz, D., Wagner, H., Miller, R.G. (1986). T-Cell Reactivity to Polymorphic MHC Determinants I. MHC-Guided T-Cell Reactivity. In: Fleischer, B., Reimann, J., Wagner, H. (eds) Specificity and Function of Clonally Developing T Cells. Current Topics in Microbiology and Immunology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71152-7_30
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DOI: https://doi.org/10.1007/978-3-642-71152-7_30
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