Abstract
There is almost universal agreement about one factor which distinguishes the T- cell repertoire from the B-cell repertoire: T-cell recognition shows MHC restriction. T cells do not recognize free antigen but only antigen on the surface of another cell. They then recognize not only the antigen but part of the cell presenting it, in particular molecules coded for within the MHC. Specificity is then for the (foreign) antigen and the (self) MHC structure. Specificity is further restricted in that private, allelically distributed epitopes of MHC molecules form part of the structure recognized.
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© 1986 Springer-Verlag Berlin Heidelberg
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Miller, R.G. (1986). Introductory Remarks. In: Fleischer, B., Reimann, J., Wagner, H. (eds) Specificity and Function of Clonally Developing T Cells. Current Topics in Microbiology and Immunology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71152-7_29
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DOI: https://doi.org/10.1007/978-3-642-71152-7_29
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71154-1
Online ISBN: 978-3-642-71152-7
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