Abstract
We explore the thesis that the T-cell receptor (TCR) interacts with nominal antigen and MHC antigen separately rather than with a complex formed by both antigens (Hoffmann 1984). The TCR has an innate specificity for MHC and its autoreactive potential is exercised during the maturation of the T cell in the thymus. We propose that mature T cells retain this reactivity for self.
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© 1986 Springer-Verlag Berlin Heidelberg
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Hoffmann, M.K., Chun, M., Hirst, J.A., Hämmerling, U. (1986). The T-Cell Receptor Recognizes Nominal and Self Antigen Independently. A Theoretical Alternative to the Modified Self Concept. In: Fleischer, B., Reimann, J., Wagner, H. (eds) Specificity and Function of Clonally Developing T Cells. Current Topics in Microbiology and Immunology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71152-7_28
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DOI: https://doi.org/10.1007/978-3-642-71152-7_28
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