Antiself Suppressive (Veto) Activity of Responder Cells in Mixed Lymphocyte Cultures
Self-tolerance is a fundamental property of the immune system. Both autoanti- gen-specific suppressor lymphocytes (STL) and anti-idiotype-specific STL have been suggested to be important for the maintenance of self-tolerance (Vento et al. 1984; Takemori and Rajewsky 1984). Self-tolerance has also been claimed to be maintained by a number of different lymphocyte populations mainly within the T-cell lineage. Both in vitro and in vivo, these suppressor cells downregulate cytotoxic lymphocyte precursors with reactivity against the H-2 haplotype of the suppressor cell. Suppressor cells with such antiself suppressor activity have been named veto cells (Miller 1980; Muraoka and Miller 1980). Veto cell function appears to be the property of both T lymphocytes and other lymphoid cells at many levels of cell differentiation (Miller 1980; Muraoka and Miller 1980, 1984; Rammensee et al. 1982). Recently, strong veto activity was shown to be present in allospecific cloned cytotoxic T-cell lines (Fink et al. 1984a; Claesson and Miller 1984). In this study we shall show that the responder cell population of a one-way allogeneic and of an autologous mixed lymphocyte culture (MLC) exhibits strong veto activity. We also present preliminary data showing that cells.
KeywordsMixed Lymphocyte Culture Responder Cell Graft Versus Host Disease Veto Cell Mixed Lymphocyte Reaction Culture
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