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Heterogeneity of the Signal Requirements During the Primary Activation of Resting Lyt-2+ Cytotoxic T-Lymphocyte (CTL) Precursors into Clonally Developing CTL

  • H. Wagner
  • C. Hardt
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 126)

Abstract

The in vitro requirements for cell interactions between antigen-presenting cells, T-helper cells, and cytotoxic T-lymphocyte precursors (CTL-P) for the induction of T-cell mediated cytotoxic responses has been recognized as early as 1973 (BACH et al. 1973; Wagner 1973; Cantor and Boyse 1975). After the discovery of the T-cell growth factor interleukin 2 (IL-2) (Morgan et al. 1976), it soon became clear that the T-helper cell product IL-2 (Wagner and Rollinghoff 1978) was crucial in T-T cell interactions during primary cytotoxic T-cell responses (Wagner et al. 1980a; Simon et al. 1981).

Keywords

Cytolytic Activity Signal Requirement Responder Cell Cytotoxic Effector Cell Normal Human Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. Wagner
    • 1
  • C. Hardt
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of UlmUlmGermany

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