Amniotic fluid cell and chorionic villi culture for prenatal HLA-determination
HLA-determination on placental or fetal tissue are of interest in Forensic Medicin as well as in Medical Genetics.I Forensic Medicine prenatal HLA-determination of the fetus supports a paternity diagnosis. In Medical Genetics one important aspect is prenatal diagnosis of congenital adrenal hyperplasia, as there is a close linkage between the HLA-B locus and a deficiency in 21-hydroxylase. Furthermore prenatal HLA-determination is of interest in relation to transplantation immunology.
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