Gene Frequency Distribution of F13A and F13B in U.S. Whites, Blacks, Amerindians and Mexican-Americans
Coagulation factor XIII (fibrin stabilizing factor) is the precursor of fibrinoligase and calalyses the cross-linking of fibrin mononers into fibrin polymers. FXIII in plasma consists of two subunits, A and B, with the enzymatic activity residing in the A subunit. The B subunit is thought to act as a carrier and regulator of the A subunit. Genetic polymorphisms of the A and B subunits have been described. Reports on the distribution of these polymorphisms have primarily been restricted to Caucasian and Asian populations.(1–13). For this study we phenotyped local White, Black, Mexican American and Amerindian populations using a technique of isoelectric focusing (IEF) and immunoblotting.
KeywordsSucrose Agarose Glycine Electrophoresis Gelatin
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