Gene Frequency Distribution of F13A and F13B in U.S. Whites, Blacks, Amerindians and Mexican-Americans

  • Dale D. Dykes
  • Shirley Miller
  • Herbert Polesky
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 1)


Coagulation factor XIII (fibrin stabilizing factor) is the precursor of fibrinoligase and calalyses the cross-linking of fibrin mononers into fibrin polymers. FXIII in plasma consists of two subunits, A and B, with the enzymatic activity residing in the A subunit. The B subunit is thought to act as a carrier and regulator of the A subunit. Genetic polymorphisms of the A and B subunits have been described. Reports on the distribution of these polymorphisms have primarily been restricted to Caucasian and Asian populations.(1–13). For this study we phenotyped local White, Black, Mexican American and Amerindian populations using a technique of isoelectric focusing (IEF) and immunoblotting.


Wash Buffer Fibrin Polymer Immunoblotting Technique Anode Sample Amerindian Population 
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  1. 1.
    Board, P. G., Amer. J. Hum. Genet. 1979, 31, 116–124.PubMedGoogle Scholar
  2. 2.
    Board, P. G., Amer. J. Hum. Genet. 1980, 32, 348–353.PubMedGoogle Scholar
  3. 3.
    Kera, Y., Nishimukai, H. and Yamasawa, K., Hum. Genet. 1981, 59, 360–364.PubMedCrossRefGoogle Scholar
  4. 4.
    Kera, Y. and Nishimukai, H., Hum. Genet. 1982, 32, 216218.Google Scholar
  5. 5.
    Kreckel, P., Kuhnl, P. and Spielmann, W., Blut 1982, 44, 309–314.PubMedCrossRefGoogle Scholar
  6. 6.
    Krechel, P. and Kuhnl, P., Blut 1982, 45, 337–345.CrossRefGoogle Scholar
  7. 7.
    Kuhnl, P., Krechel, P. and Spielmann, W., In 1). Stathakos (ed.) Electrophoresis ‘82. Advanced Methods Biochemical and Clinical Applications. Walter de Gruyter, Berlin, New York 1983.Google Scholar
  8. 8.
    Mauff, G., Schilling, A. and Pulverer, G., Abstr. Vol 10 Int. Cong. Soc. Forens. Haemogenet., Munich 1983, pp. 453–457.Google Scholar
  9. 9.
    Nakamura, S. and Abe, K., Ann. Hum. Genet. 1982, 46, 203–207.PubMedCrossRefGoogle Scholar
  10. 10.
    Nishigaki, T., Omoto, K. and Juju, T., Jpn. J. Hum. Genet. 1981, 26, 237–241.CrossRefGoogle Scholar
  11. 11.
    Nishigaki, T. and Omoto, K., Jpn. J. Hum. Genet. 1982, 27, 265–270.CrossRefGoogle Scholar
  12. 12.
    Olaisen, B., Siverts, S., Toias, G-D., Jonassen, P. and Teisberg, P., Abstr. Vol. 10 Int. Cong. Soc.’ Forens. Haemogenet., Munich 1983, pp. 459–463.Google Scholar
  13. 13.
    Weidinger, S., Schwarzfischer, F., Leifheit, H.-J. and Cleve, H., Abstr. Vol 10 Int. Cong. Forens. Haemogenet., Munich 1983, pp. 447–452.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Dale D. Dykes
    • 1
  • Shirley Miller
    • 1
  • Herbert Polesky
    • 1
  1. 1.Memorial Blood Center of MinneapolisMinneapolisUSA

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