Abstract
The HLA system which represents the major histocompatibility complex of man encompasses approximately one thousandth of the human genome. It is governed by a gene complex situated on the short arm of chromosome 6 (between 6p21.1 and 6p21.3) and contains a series of closely linked loci (for review, see Histocompatibility Testing 1984):
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HLA-A, B and C coding glycosilated polypeptides with a molecular weight of 44000 daltons (on the cell surface, these chains are noncovalently bound to ß2-microglobulin, a polypeptide governed by chromosome 15)
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the HLA-D region with loci for α and ß chains (glycosilated poly-peptides with 34000 and 29000 daltons, respectively)
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at least 4 loci for proteins of the complement system (C2, C4A, C4B and Bf)
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loci for the 21-hydroxylase.
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References
Histocompatibility Testing 1984, Albert ED, Baur MP, Mayr WR, eds, Springer, Berlin 1984
Mayr WR: Probleme bei der Anwendung des HLA Systems im Vaterschafts-gutachten. Referate 7. int. Tagung Ges. f. forens. Blutgruppenkunde, Hamburg, 1977, S. 417
Mayr WR, Waltz H, Wegener R: Das HLA System in der Vaterschaftsserologie: praktische Erfahrungen bei 1130 Fällen. In: Biomathematical Evidence of Paternity, Hummel K, Gerchow J, eds, Springer, Berlin 1981, p. 177
Waltz H, Prokop O, Mayr WR: HLA-DR in der Paternitätsbegutachtung. Referate 10. int. Tagung Ges. f. forens. Blutgruppenkunde, München, 1983, S. 41
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© 1986 Springer-Verlag Berlin Heidelberg
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Mayr, W.R. (1986). The HLA System in Forensic Practice. In: Brinkmann, B., Henningsen, K. (eds) 11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.). Advances in Forensic Haemogenetics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71150-3_5
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DOI: https://doi.org/10.1007/978-3-642-71150-3_5
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