Abstract
Immunoglobulins of the IgG class can be divided into four isotypes, IgG1, IgG2, IgG3 and IgG4, on the basis of the amino acid differences in the heavy chain constant region, of variation in the position of attachment of light to heavy chain, and of the number and arrangement of inter-heavy chain disulfide bridges (1,2). These structural differences are reflected in unique antigenic determinants that allow their serologic recognition and in a series of allotypic determinants of gamma markers (Gm) that reflect genetically controlled polymorphisms (1–3).
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Matsumoto, H., Ito, S., Miyazaki, T., Kawai, N. (1986). Structural Studies of Another Human IgG3 Myeloma Protein (Kam) Carrying the Allotypic Markers Gm(s,t) and Its Alterration Induced by Chemical Modification. In: Brinkmann, B., Henningsen, K. (eds) 11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.). Advances in Forensic Haemogenetics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71150-3_32
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DOI: https://doi.org/10.1007/978-3-642-71150-3_32
Publisher Name: Springer, Berlin, Heidelberg
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