Investigations on the C8 System by Immunofixation Isoelectrofocusing

  • Peter Kühnl
  • Wolfgang Lenz
  • Willi Spielmann
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 1)


A genetic polymorphism of the eighth component of human complement (C8) was detected in 1977 by RAUM et al. who used a functional, hemolytic detection system. In the following years the three-chain structure of C8 (C8 α, β, γ) posed numerous questions concerning the formal genetic model. The interpretation of C8 phenotypes was complicated by the fact that activity zones were present at different pI values. In 1983 ALPER et al. reported on a C8 β-subunit polymorphism, subsequently called C82 in contrast to the C81 (α-γ) polymorphism detected 6 years ago. Population data on the C8 systems are scarce.


Human Complement Human Gene Mapping Exclusion Chance Anodal Edge Fresh Serum Sample 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Peter Kühnl
    • 1
  • Wolfgang Lenz
    • 1
  • Willi Spielmann
    • 1
  1. 1.Institute of ImmunohematologyUniversity FrankfurtFrankfurt am MainGermany

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