Abstract
The fourth component of complement (C4) in man has an important central role in the classical pathway of complement activation. It interacts with other complement components (C1, C2, C3) and binds covalently to antibody or antigen on cell surfaces. The highly complex polymorphism is thought to relate to its diversity of function (Porter 1983) and is limited, with one reported exception (Mauff et al. 1983a), to the ∝ chain of the molecule or more precisely to the C4d (∝2) fragment (Tilley et al. 1978, Mevag et al. 1981). Since the C4d fragment contains structures involved in the activation, inactivation and covalent binding of C4 and also 13 of the 15 reported nucleotide sequence differences (Belt et al. 1985), Porter suggests that the ∝ chain is probably on the exterior of the C4 molecule.
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© 1986 Springer-Verlag Berlin Heidelberg
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Giles, C.M. (1986). Polymorphism of C4 with Special Reference to the Serological Determinants, Rodgers and Chido. In: Brinkmann, B., Henningsen, K. (eds) 11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.). Advances in Forensic Haemogenetics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71150-3_14
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DOI: https://doi.org/10.1007/978-3-642-71150-3_14
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