Fecal Chymotrypsin in Chronic Pancreatitis Disease

  • G. Adler
  • F. Weidenbach


The diagnostic value of fecal tryptic activity in pancreatic insufficiency was first described in 1908 by Schlecht [23]. Due to the lack of specific substrates, only semiquantitative methods, which measured the total proteolytic enzyme activity in stool, were available until the middle of this century. Between 1948 and 1950 Neurat and Schwert [20] described low molecular weight, specific substrates for chymotrypsin which were first used experimentally in a titrimetric pH-stat method by Grossman and coworkers [7, 21].


Anorexia Nervosa Pancreatic Insufficiency Photometric Method Exocrine Pancreatic Function Chymotrypsin Activity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • G. Adler
    • 1
  • F. Weidenbach
  1. 1.Department of Internal Medicine, Division of GastroenterologyPhillipps UniversityMarburgGermany

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