Abstract
The test compound of the pancreolauryl test (PLT) is administered orally in capsules. Pancreas-specific cholesterolesterhydrolase induces hydrolysis of the compound into lauric acid and free water-soluble fluorescein (Fig. 1). Fluorescein is absorbed from the gut and excreted into the urine. The urine is collected for 10 h, and the amount of fluorescein excreted into the urine is directly proportional to the activity of the esterase and taken as an index of pancreatic function.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Barry RE, Barry R, Ene MK, Parker G (1982) Fluorescein dilaurate-tubeless test for pancreatic exocrine failure. Lancet 2: 742–744
Boyd EJS, Cumming JGR, Cuschieri A, Wood RAB, Wormsley KG (1982) Prospective comparison of the fluorescein-dilaurate test with the secretin-cholecystokinin test for pancreatic exocrine function. J Clin Pathol 35: 1240–1243
Cavallini G, Piubello W, Brocco G, Vantini I, Angelini G, Benini L, Chech G, Marchiaro G, Dobrilla G, Bonoldi C, Scuro LA (1983) Reliability of the Bz-Ty-PABA and the pancreolauryl test in the assessment of exocrine pancreatic function. Digestion 27: 129–137
DiMagno EP, Go VLW, Summerskill WHJ (1973) Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 288: 813–815
Freise J, Ranft U, Fricke K, Schmidt FW (1984) Chronische Pankreatitis: Sensitivität, Spezifität und prädiktiver Wert des Pankreolauryltests. Z Gastroenterol 22: 705–712
Gyr K, Felsenfeld O, Imondi AR (1978) Chymotrypsin-like activity of some intestinal bacteria. Am J Dig Dis 23: 413–116
Kaffarnik H, Klimkeit P, Zöfel P, Otte U, Meyer-Bertenrath JG (1977) Zur klinischen Wertigkeit des oralen Pankreasfunktionstests mit Fluoreszein-Dilaurat. Münch Med Wo- chenschr 119: 1467–1470
Kay G, Hine P, Braganza J (1982) The pancreolauryl test: a method of assessing the combined functional efficacy of pancreatic esterase and bile salts in vivo? Digestion 24: 241–245
Lankisch PG, Schreiber A, Otto J (1983) Pancreolauryl test. Evaluation of a tubeless pancreatic function test in comparison with other indirect and direct tests for exocrine pancreatic function. Dig Dis Sci 28: 490–493
Lankisch PG, Brauneis J, Otto J, Göke B (1986) Pancreolauryl and NBT-PABA tests: are serum tests more practicable alternatives to urine tests in the diagnosis of exocrine pancreatic insufficiency? Gastroenterology 90: 350–354
Lankisch PG, Otto J, Brauneis J, Lembcke B (1986) Quantitative assessment of decompensated exocrine pancreatic insufficiency by oral pancreatic function tests, (submitted for publication)
Malfertheiner P, Peter M, Junge U, Ditschuneit H (1983) Der orale Pankreasfunktionstest mit FDL in der Diagnose der chronischen Pankreatitis. Klin Wochenschr 61: 193–198
Malfertheiner P, Junge U, Ditschuneit H (1984) Pancreatic digestive function after subtotal gastrectomy - evaluation by an indirect method. Hepatogastroenterology 31: 172–175
Stock K-P, Schenk J, Schmack B, Domschke W (1981) Funktions-Screening des exokrinen Pankreas. FDL-, N-BT-PABA-Test, Stuhl-Chymotrypsinbestimmung im Vergleich mit dem Sekretin-Pankreozymin-Test. Dtsch Med Wochenschr 106: 983–987
Ventrucci M, Gullo L, Daniele C, Priori P, Labo G (1983) Pancreolauryl test for pancreatic exocrine insufficiency. Am J Gastroenterol 78: 806–809
Wildgrube HJ, Schröter R, Classen M (1982) Exkretorische Pankreasfunktion: Vergleich indirekter Funktionsprüfungen mit dem Sekretin-Cholecystokinin-Test. Dtsch Med Wo¬chenschr 107: 1751–1755
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Lankisch, P.G. (1986). The Indirect Pancreatic Function Test “Pancreolauryl” in Chronic Pancreatitis. In: Malfertheiner, P., Ditschuneit, H. (eds) Diagnostic Procedures in Pancreatic Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71128-2_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-71128-2_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71130-5
Online ISBN: 978-3-642-71128-2
eBook Packages: Springer Book Archive