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Diagnostic Procedures in Pancreatic Disease pp 215–222Cite as

Indirect Pancreatic Function Test with NBT-PABA

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Abstract

In 1972 Imondi et al. [12] first reported reliable results in animals with a simple oral pancreatic function test involving the chymotrypsin-labile peptide N-benzoyl-L-tyrosyl-paraaminobenzoic acid (BT-PABA).

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References

  1. Arvanitakis C, Greenberger N (1976) Diagnosis of pancreatic disease by a synthetic peptide: a new test of exocrine pancreatic function. Lancet 1: 663–666

    Article  PubMed  CAS  Google Scholar 

  2. Bornschein W, Goldmann FL, Otte M (1976) Methodische und erste klinische Untersuchungsergebnisse mit einem neuen indirekten Pankreasfunktionstest. Clin Chim Acta 67: 21–27

    Article  PubMed  CAS  Google Scholar 

  3. Bornschein W, Goldmann FL, Dressler J (1978) Diagnostik der exokrinen Pankreasinsuffi- zienz mit einem synthetischen chymotrypinspezifischen Peptid. Klin Wochenschr 56: 197–205

    Article  PubMed  CAS  Google Scholar 

  4. Braganza JM, Kay GH, Tetlow VA, Herman KJ (1983) Observations on the BTABA/14C- PABA tubeless test of pancreatic function. Chir Chim Acta 130: 339–347

    CAS  Google Scholar 

  5. Cavallini G, Piubello W, Brocco G, Barba E, Baratta S, Dobrilla G, Parolin P, Bonoldi C, Scuro LA (1980) Urinary PABA recovery after oral TV-benzoyl-L-tyrosyl-PABA administration combined with various exocrine pancreatic stimulants. Hepato-Gastroenterol 27: 224–226

    CAS  Google Scholar 

  6. Cavallini G, Piubello W, Brocco G, Vantini I, Angelini G, Benini L, Chech G, Marchiaro G, Dobrilla G, Bonoldi C, Scuro LA (1983) Reliability of the Bz-Ty-PABA and the pancreo- lauryl test in the assessment of exocrine pancreatic function. Digestion 27: 129–137

    Article  PubMed  CAS  Google Scholar 

  7. Delchier JC, Soule JC (1983) BT-PABA test with plasma PABA measurements: evaluation of sensitivity and specificity. Gut 24: 318–325

    Article  PubMed  CAS  Google Scholar 

  8. Freise J, Hofmann R (1979) Zur Spezifität des Peptid-PABA-Tests. Z Gastroenterol 17: 310–317

    PubMed  CAS  Google Scholar 

  9. Gyr NE (1975) Tests of exocrine pancreatic function. Huber, Bern (Current problems in clinical biochemistry 5 )

    Google Scholar 

  10. Harada H, Mishima K, Shundo T, Yamamoto N, Sasaki T, Hinofuji T, Hayashi T, Uchida Y, Kimura I (1979) Exocrine pancreatic function test by a synthetic peptide. Am J Gastroenterol 71: 45–52

    PubMed  CAS  Google Scholar 

  11. Hosoda S, Kashima K, Bamba T, Kinugasa K, Nakaki T, Masuda M (1979) PFD, a new test of exocrine pancreatic function using BT-PABA (Bentiromide). In: Masuda M (ed) Pancreatic function diagnostant. Igaku-Shoin, Tokyo, pp 27–37

    Google Scholar 

  12. Imondi AR, Stradley RP, Wolgemuth R (1972) Synthetic peptides in the diagnosis of exocrine pancreatic insufficiency in animals. Gut 13: 726–731

    Article  PubMed  CAS  Google Scholar 

  13. Imondi AR, Wolgemuth RL (1979) Improved sensitivity of the BT-PABA pancreatic function test in animals with meals of raw egg white. Am J Dig Dis 24: 214–216

    Article  CAS  Google Scholar 

  14. Kuwahara S, Abe M, Inoue S, Kubo Y, Tanikawa K (1980) Test meal combined PFD. Its experimental study and clinical evaluation. In: Masuda M (ed) Pancreatic function diagnostant. Igaku-Shoin, Tokyo, pp 114–121

    Google Scholar 

  15. Lang C, Gyr K, Borer P, Kayasseh L, Stalder GA (1980) Die Prüfung der exokrinen Pankreasfunktion mit oral verabreichter N-Benzoyl-L-Tyrosyl-Paraaminobenzoesäure ( BT-PA- BA-Test ). Schweiz Med Wochenschr 110: 522–528

    Google Scholar 

  16. Lang C, Gyr K, Kraehenmann JA, Arenz F (1980) The oral pancreatic function test with N-benzoyl-L-tyrosyl-p-aminobenzoic acid: acute toxicity and effect of renal function on this test. J Clin Chem Clin Biochem 18: 551–555

    PubMed  CAS  Google Scholar 

  17. Lang C, Gyr K, Lankisch PG (1984) The combined pancreolauryl-BT-PABA test - an improved tubeless pancreatic function test? Digestion 30: 110

    Google Scholar 

  18. Lang C, Gyr K, Stalder GA, Gillessen D (1981) Assessment of exocrine pancreatic function by oral administration of JV-benzoyl-L-tyrosyl-p-aminobenzoic acid (Bentiromide): 5 years’ clinical experience. Br J Surg 68: 771–775

    Article  PubMed  CAS  Google Scholar 

  19. Lang C, Gyr K, Tonko I, Conen D, Stalder GA (1984) Value of serum PABA as a pancreatic function test. Gut 25: 508–512

    Article  PubMed  CAS  Google Scholar 

  20. Lang C, Gyr K (1985) European experience with the BT-PABA test (Bentiromide). Submitted for publication

    Google Scholar 

  21. Lankisch PG, Ehrhardt-Schmelzer W, Koop H, Caspary WF (1980) Der NBT-PABA-Test in der Diagnostik der exokrinen Pankreasinsuffizienz. Dtsch Med Wochenschr 105: 1418–1423

    Article  PubMed  CAS  Google Scholar 

  22. Lankisch PG, Schreiber A, Otto J (1983) Pancreolauryl test: evaluation of a tubeless pancreatic function test in comparison with other indirect and direct tests for exocrine pancreatic function. Dig Dis Sci 28: 490–493

    Article  PubMed  CAS  Google Scholar 

  23. Malis F, Fric P, Kasafirek E, Slaby J (1978) Functional examination of the pancreatic secretion with 4-(7V-acetyl-L-tyrosyl) aminobenzoic acid. Acta Hepato-Gastroenterol 25: 233–237

    CAS  Google Scholar 

  24. Mitchell CJ, Humphrey CS, Bullen AW, Kelleher J (1978) The diagnostic value of the oral pancreatic function test. Scand J Gastroenterol 14: 183–187

    Article  Google Scholar 

  25. Mitchell CJ, Humphrey CS, Bullen AW, Kelleher J, Losowsky MS (1979) Improved diagnostic accuracy of a modified oral pancreatic function test. Scand J Gastroenterol 14: 737–741

    Article  PubMed  CAS  Google Scholar 

  26. Ribet A, Frexinos J, Escourrou J, Vaysse N, Arany Y, Varignon M (1979) Etude indirecte de la sécrétion exocrine du pancréas par administration orale d’un peptide synthétique ( PABA test ). Gastroenterol Clin Biol 3: 227–234

    Google Scholar 

  27. Sterchi EE, Green JR, Lentze MJ (1982) Non-pancreatic hydrolysis of N-benzoyl-L-tyrosyl- p-aminobenzoic acid ( PABA-peptide) in the human small intestine. Clin Sci 62: 557–560

    Google Scholar 

  28. Stock KP, Schenk J, Schmack B, Domschke W (1981) Funktions,,Screening; des exokrinen Pankreas. Dtsch Med Wochenschr 106: 983–987

    Article  PubMed  CAS  Google Scholar 

  29. Thienhaus R, Niederau C (1979) Die Untersuchung der exokrinen Pankreasfunktion mit N- Benzoyl-L-Tyrosyl-p-Aminobenzoesäure. Z Gastroenterol 17: 187–194

    PubMed  CAS  Google Scholar 

  30. Toskes PP (1983) Bentiromide as a test of exocrine pancreatic function in adult patients with pancreatic exocrine insufficiency. Gastroentrology 85: 565–569

    CAS  Google Scholar 

  31. Wildgrube HJ, Schroeter R, Classen M (1982) Exkretorische Pankreasfunktion: Vergleich indirekter Funktionsprüfungen mit dem Sekretin-Cholezystokinin-Test. Dtsch Med Wochenschr 107: 1751–1755

    Google Scholar 

  32. Wolf Ch, Ehrig C, Brunner H (1981) Paraaminobenzoesäurespiegel im Serum nach Gabe von N-Benzoyl-L-Tyrosyl-p-araaminobenzoesäure als Suchtest der exkretorischen Pankreasinsuffizienz. Schweiz Med Wochenschr 111: 343–347

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Gastroenterology, St. Claraspital and University Hospital/Kantonsspital Basel, CH-4058, Basel, Switzerland

    C. Lang

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  1. C. Lang
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  2. K. Gyr
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Editors and Affiliations

  1. Abteilung Innere Medizin II, Medizinische Universitätsklinik, Steinhövelstraße 9, D-7900, Ulm/Donau, Germany

    Peter Malfertheiner  & Hans Ditschuneit  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Lang, C., Gyr, K. (1986). Indirect Pancreatic Function Test with NBT-PABA. In: Malfertheiner, P., Ditschuneit, H. (eds) Diagnostic Procedures in Pancreatic Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71128-2_32

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  • DOI: https://doi.org/10.1007/978-3-642-71128-2_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71130-5

  • Online ISBN: 978-3-642-71128-2

  • eBook Packages: Springer Book Archive

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