Antiproteases and Nonspecific Inflammatory Parameters in the Monitoring of Acute Pancreatitis

  • M. J. McMahon
Conference paper


During acute pancreatitis high concentrations of pancreatic enzymes are found in plasma, changes occur in the levels of plasma antiproteases and a brisk acute phase response results. Developments in various techniques of immunoassay have enabled many of these changes to be quantified using methods which can be adapted for use in the routine clinical biochemistry laboratory. The aim of this chapter is to review the current status of these assays in the management of patients with acute pancreatitis.


Acute Pancreatitis Pancreatic Necrosis Severe Attack DNase Activity Pancreatic Abscess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kivilaakso E, Lempinen M, Mäkelamea A, Nikki P, Schröder T (1984) Pancreatic resection us peritoneal lavation for acute fulminant pancreatilis. Ann Surg 199: 426–431PubMedCrossRefGoogle Scholar
  2. 2.
    Mero M, Schröder’r T, Tenhunen R, Lempinen M (1982) Serum phosphohpase A2, immucaclive trypsia and l,ypsia inhibitors during human acute pancreatitis. Scand J Gastroentesterol 17: 413–416CrossRefGoogle Scholar
  3. 3.
    McMahon MJ, Bowen M, Mayer AD, Cooper EH (1984) Relationship of alpha2-macroglobulin and other antiproteases to the clinical features of acute pancrealitis. Am J Surg 147:164–170PubMedCrossRefGoogle Scholar
  4. 4.
    Kowlessar OD,MrEvoy RK(1956)Desoxyribonuclease I in pancreatic disease. J Clin Invest 35:1325–1330PubMedCrossRefGoogle Scholar
  5. 5.
    Reitz, M, Neher, M, Zöllner EJ, Zahn RK (1981) Serum DNase activity after experimental acute hemorrhagic-necrotizing pancreatitis in dogs: delection of a serum DNase isoenzyme. Eur Surg Res 13: 269–277PubMedCrossRefGoogle Scholar
  6. 6.
    Warshaw AL, Lee K-H (1979) Scrum ribonuclease elevations and pancreatic necrosis in acute pancreatitis. Surgery 86: 227–234PubMedGoogle Scholar
  7. 7.
    Balldin G, Eddeland A, Ohlsson K (1981) Studies on the role of the plasma protease inhibitors on in-vitro C 3 activation and in acute pancreatitis. Scand J Gastroenterol 16: 603–609PubMedCrossRefGoogle Scholar
  8. 8.
    Cuschieri A, Wood RAB, Cumming JRG, Meehan SE, Mackie CR (1983) Treatment of acute pancreatitis wish fresh frozen plasma. Br J Surg, 70: 710–712PubMedCrossRefGoogle Scholar
  9. 9.
    Mayer AD, McMahon MJ, Bowen M, Cooper EH (1984) C-reactive protein: an aid to assessment and monitoring of acute, pancreatitis. J Clin Pathol 137: 207–211CrossRefGoogle Scholar
  10. 10.
    Lankisch PG, Koop H, Kaboth V (1981) Serum complement factors in human acute pancreatitis. Hepatogastroenterol 28: 261–263Google Scholar
  11. 11.
    Foulis AK, Murray W R, Galloway D, McCartney AC, Lange E, Witch J, Whaley K (1982) Endotoxaemia and complement activation in acute pancreatitis in man. Gut 23: 665–661CrossRefGoogle Scholar
  12. 12.
    Whicher JT, Barnes MP, Brown A, Cooper MJ, Read R, Walters G, Welliamson RCN (1982) Complement activation and complement control proteins in acute pancreatitis. Gut 23: 944–950PubMedCrossRefGoogle Scholar
  13. 13.
    Pott G, Krummeneral T, Lohmann J, Clemens M(1982)Fibronectin as a prognostic parameter in patients suffering from panereatogenic shock. In: Hollender LF (ed) Controversies in acute pancreatitis. Springer, Berlin Heidelberg New York, pp 48–49Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • M. J. McMahon
    • 1
  1. 1.University Department of SurgeryGeneral InfirmaryLeedsUK

Personalised recommendations