Abstract
Pancreatic enzymes are found in the circulation in low concentrations — in the nanomolar range per milliliter compared with their concentrations in pancreatic juice, where they are secreted in concentrations up to several milligrams per milliliter. The output of pancreatic enzymes from the exocrine pancreatic cell into the pancreatic duct is changeable due to the physiological or pathophysiological status of the pancreatic secretion — basal, physiological stimuli such as a meal, pharmacological stimuli with, e.g., hormone infusions or pancreatic disease. In the circulation, the concentration of pancreatic enzymes is regulated on a quite constant level in the basal or physiologically stimulated status; only under pharmacological stimuli or in pancreatic or some extrapancreatic (e.g., renal) disease may their level be increased.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Götze H, Rothman SS (1975) Enteropancreatic circulation of digestive enzymes as a conservation mechanism. Nature 257: 607–609
Heinrich HC, Gabbe EE, Brüggemann J, Icagic F, Classen M (1979) Enteropancreatic circulation of trypsin in man. Klin Wochenschr 57: 1295–1297
Lake-Bakaar G, Smith-Laing G, Summerfield JA (1982) Origin of circulating serum immun-reactive trypsin in man. Dig Dis Sci 27: 143–148
Skogh T (1982) Overestimate of 125I-protein uptake from the adult mouse gut. Gut 23: 1077–1080
Levitt MD, Ellis CJ, Murphy SM, Schwartz ML (1981) Study of the possible enteropancreatic circulation of pancreatic amylase in the dog. Am J Physiol 241: G54–G58
Malfertheiner P, Ditschuneit H, Bieger W (1983) Circulating trypsin. Dig Dis Sci 28: 285–286
Borgström A, Ohlsson K (1976) Radioimmunologic determination and characterisation of cathodal trypsin like immunoreactivity in normal human plasma. Scand J Clin Lab Invest 36: 809–814
Janowitz HD, Hollander F (1951) The exocrine partition of enzymes in the digestive tract. Gastroenterology 17: 591–593
Dumont AF, Doubillet H, Mulholland JH (1960) Lymphatic pathway of pancreatic secretion in man. Ann Surg 152: 403–09
Papp M, Feher S, Nemeth EP, Somogyi J, Folly G (1980) Exit routes for secretory proteins from the dog pancreas Acta physiol. Acad Sci Hung 56: 401–410
Geokas ML, Largman C, Broderick JW, Fasett M (1980) Molecular forms of immunoreactive pancreatic elastase in canine pancreatic and peripheral blood. Am J Physiol 238:G238– G246
Saito A, Kanno T (1973) Concentration of pancreozymin as a determinant of the exocrine endocrine partition of pancreatic enzymes. Jpn J Physiol 23: 477–495
Adler G, Rohr G, Kern HF (1982) Alteration of membrane fusion as a cause of acute pancreatitis in the rat. Dig Dis Sci 27: 993–1002
Reber HA, Farmer RC (1982) Effects of acute ethanol and aspirin ingestion on pancreatic duct permeability to macromolecules. Digestion 25: 64
Kuijpers GAJ, Vossen MEMM, Stadhouders AH, de pont JJHHM, Bonting SL (1982) the paracellular secretory pathway in the rabbit pancreas. Digestion 25: 46–47
Rohr G, Keim V, Burkhard R, Reschke W (1983) Pancreatic duct permeability to exocrine pancreatic enzymes. Digestion 28: 100–101
Ryan J, Appert H (1975) Circulatory turnover of pancreatic amylase. Proc Soc Exp Biol Med 149: 921–925
Bieger W, Trischler G, Malferteiner P (1982) Dissoziation von Amylase and Trypsin nach Stimulation mit Sekretin and Pankreozymin. Klin Wochenschrift 60: 1363–1368.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rohr, G. (1986). Entry of Pancreatic Enzymes into the Circulation. In: Malfertheiner, P., Ditschuneit, H. (eds) Diagnostic Procedures in Pancreatic Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71128-2_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-71128-2_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71130-5
Online ISBN: 978-3-642-71128-2
eBook Packages: Springer Book Archive