Changes in Brain Blood Flow and Organ Function Following Treatment of Primary Hypertension

  • W.-D. Heiss
Conference paper


The importance of antihypertensive treatment is evident from epidemiologic data on hypertension as a risk factor for stroke. According to the Framingham Study [1, 2] the systolic blood pressure is the most important risk factor, followed by diabetes, cardiac insufficiency, nicotine abuse, and hyperlipidemia. A hypertensive person’s risk of suffering a stroke within 16 years is seven times that of a normotonic. Incidence of stroke is increased 5 to 30 times depending on severity of hypertension, age, and sex. The risk does not increase proportionally with hypertension (as is the case for myocardial infarction), but rises more than linearly for higher values (180 mmHg systolic pressure). Hypertension is especially risky for younger men and older women. Ischemic as well as hemorrhagic strokes are more frequent in hypertensive patients, and the risk may be directly read from the systolic value, where a fast increase within a short period of observation indicates an exceptionally high risk for cerebrovascular disease [3].


Cerebral Blood Flow Cerebrovascular Disease Antihypertensive Treatment Primary Hypertension Hypertensive Encephalopathy 
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Copyright information

© Springer-Verlag Berlin Heildelberg 1986

Authors and Affiliations

  • W.-D. Heiss
    • 1
  1. 1.Max-Planck-Institut für neurologische Forschung und Neurologische Klinik des Stadtischen Krankenhauses Köln-MerheimKöln 91 (Merheim)Germany

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