The Role of Local Anesthetic Effects in the Actions of Antiarrhythmic Drugs

  • G. A. Gintant
  • B. F. Hoffman
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 81)


Pharmacologic therapy is the most common therapeutic approach towards the control and treatment of cardiac arrhythmias. The therapeutic efficacy of antiarrhythmic drugs may derive from any number (or combination) of actions, including effects on the central nervous system, sympatholytic effects, as well as direct and/or indirect effects on active and passive properties of cardiac membranes (including sodium, calcium, and potassium channels, gap junctions, and exchange mechanisms). A majority of antiarrhythmic drugs have demonstrated local anesthetic effects, in that they reduce the fast inward sodium current of cardiac fibers. It is the purpose of this review to briefly discuss the contributions of local anesthetic effects to the actions of antiarrhythmic agents.


Antiarrhythmic Drug Action Potential Duration Purkinje Fiber Circus Movement Cardiac Sodium Channel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • G. A. Gintant
  • B. F. Hoffman

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