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Pharmacokinetics of Local Anesthetics

  • G. R. Arthur
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 81)

Abstract

Utilizing the pharmacokinetics of local anesthetic agents has different emphasis than for most other drugs, as these agents are applied directly to the site of their action rather than being transported in the blood stream to this site. Toxic reactions to local anesthetics are usually associated with the accidental intravenous injection of drug, but toxic effects can occur in normal usage. A knowledge of how the body handles these agents will help in understanding why these reactions can occur and also their different pharmacological behaviour.

Keywords

Local Anesthetic Plasma Protein Binding Hepatic Blood Flow Total Body Clearance Hepatic Extraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1987

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  • G. R. Arthur

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